Endothelial cell markers in vascular neoplasms: an immunohistochemical study comparing factor VIII-related antigen, blood group specific antigens, 6-keto-PGF1 alpha, and Ulex europaeus 1 lectin.

Abstract

Markers for endothelial cells including Ulex europaeus 1 lectin, blood group A, B, and H, and the prostaglandin metabolite 6-keto-PGF1 alpha were evaluated in paraffin secretions from formalin-fixed benign and malignant vascular neoplasms using a variety of immunohistochemical techniques, and results compared with staining for factor VIII-related antigen. Staining for Ulex appeared more sensitive than factor VIII-related antigen in identifying poorly differentiated neoplasms including haemangiosarcomas and spindle cell proliferations in Kaposi's sarcoma. Staining for blood group related antigens correlated with blood group in all cases. Ulex europaeus 1 lectin was the only marker for endothelial cells in lymphangiomas.

• Authors: D Little, J W Said, R J Siegel, M Fealy, M C Fishbein
• Journal: The Journal of pathology (J Pathol) Vol. 149 Issue 2 Pg. 89-95 (Jun 1986) ISSN: 0022-3417 [Print] England
• PMID: 2426432 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antigens
• Antigens, Neoplasm
• Blood Group Antigens
• Isoantigens
• Lectins
• Plant Lectins
• Ulex europaeus lectins
• von Willebrand Factor
• 6-Ketoprostaglandin F1 alpha
• Factor VIII

Topics

• 6-Ketoprostaglandin F1 alpha (analysis)
• Antigens (analysis)
• Antigens, Neoplasm (analysis)
• Blood Group Antigens (immunology)
• Endothelium (pathology)
• Factor VIII (analysis, immunology)
• Humans
• Isoantigens (analysis)
• Lectins (immunology)
• Neoplasms, Vascular Tissue (immunology, pathology)
• Plant Lectins
• Staining and Labeling (methods)
• von Willebrand Factor