Neuromodulation for dystonia: target and patient selection.

Abstract

Treatment of dystonia refractory to oral medications or botulinum toxin injections includes the use of deep brain stimulation (DBS). Expectations should be established based on patient-related factors, including type of dystonia, genetic cause, target symptoms, age at the time of surgery, disease duration, or the presence of fixed skeletal deformities. Premorbid conditions such as psychiatric illness and cognitive impairment should be considered. Target selection is an emerging issue in DBS for dystonia. Although efficacy has been established for targeting the globus pallidus internus for dystonia, other brain targets such as the subthalamic nucleus, thalamus, or cortex may be promising alternatives.

• Authors: Kelly A Mills, Philip A Starr, Jill L Ostrem
• Journal: Neurosurgery clinics of North America (Neurosurg Clin N Am) Vol. 25 Issue 1 Pg. 59-75 (Jan 2014) ISSN: 1558-1349 [Electronic] United States
• PMID: 24262900 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2014 Elsevier Inc. All rights reserved.

Topics

• Deep Brain Stimulation
• Dystonia (therapy)
• Humans
• Patient Selection
• Prognosis
• Treatment Outcome