Abstract | INTRODUCTION: METHODS: The database of biopsy reports obtained between 2006 and 2009 was searched for specimens diagnosed as radicular cysts or periapical granulomas. Only data relating to biopsies obtained from adolescent (13-21 years old) and elderly (over 60 years old) patients were selected. The biopsies were examined by a pathologist under a light microscope (Zeiss, Jena, Germany) at magnifications of 40×-200×. The available material was scanned for the presence of cholesterol clefts and foamy cells in radicular cysts and granulomas. RESULTS: A total of 41 specimens were collected in the adolescent group and 48 specimens in the elderly group over a 4-year period. A higher incidence of cholesterol was found in the elderly group compared with that in the adolescent group (odds ratio = 6.857). CONCLUSIONS: The highly significant incidence of cholesterol deposits in periapical biopsies among elderly patients may be a possible cause for the lack of repair. The mechanism for cholesterol accumulation is probably similar to the process leading to atherosclerosis and coronary artery disease. Statin administration may be advantageous for the treatment of persistent lesions. A clinician should be aware of the risk for persistent lesions after endodontic treatment in elderly patients.
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Authors | Iris Slutzky-Goldberg, Valery Baev, Alexander Volkov, Avi Zini, Igor Tsesis |
Journal | Journal of endodontics
(J Endod)
Vol. 39
Issue 12
Pg. 1477-80
(Dec 2013)
ISSN: 1878-3554 [Electronic] United States |
PMID | 24238432
(Publication Type: Journal Article)
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Copyright | Copyright © 2013 American Association of Endodontists. Published by Elsevier Inc. All rights reserved. |
Chemical References |
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Topics |
- Adolescent
- Age Factors
- Aged
- Biopsy
(methods)
- Cholesterol
(analysis)
- Female
- Foam Cells
(pathology)
- Follow-Up Studies
- Humans
- Male
- Middle Aged
- Periapical Granuloma
(metabolism, pathology)
- Periapical Periodontitis
(metabolism, pathology)
- Radicular Cyst
(metabolism, pathology)
- Retrospective Studies
- Young Adult
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