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Radicular Cyst

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Slow-growing fluid-filled epithelial sac at the apex of a tooth with a nonvital pulp or defective root canal filling.

Also Known As:

Apical Periodontal Cyst; Apical Periodontal Cysts; Cyst, Apical Periodontal; Cyst, Periapical; Cyst, Radicular; Cysts, Apical Periodontal; Cysts, Periapical; Cysts, Radicular; Periapical Cysts; Periodontal Cysts, Apical; Radicular Cysts; Periapical Cyst; Periodontal Cyst, Apical

Networked: 220 relevant articles (9 outcomes, 56 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Cysts
2.	Odontogenic Cysts (Keratocyst)
3.	Inflammation
4.	Periodontitis
5.	Chronic Periodontitis

Experts

1.	de Almeida Freitas, Roseana: 5 articles (11/2013 - 07/2004)
2.	Galvão, Hébel Cavalcanti: 5 articles (11/2013 - 12/2008)
3.	Li, Song: 3 articles (06/2015 - 06/2012)
4.	Freitas, Roseana de Almeida: 3 articles (08/2013 - 04/2002)
5.	Nonaka, Cassiano Francisco Weege: 3 articles (08/2013 - 12/2008)
6.	Fregnani, Eduardo Rodrigues: 3 articles (10/2012 - 01/2011)
7.	de Souza, Lélia Batista: 3 articles (10/2011 - 07/2004)
8.	Rados, Pantelis Varvaki: 2 articles (12/2015 - 05/2008)
9.	Chen, Gang: 2 articles (01/2015 - 07/2014)
10.	Bijani, Ali: 2 articles (01/2015 - 01/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Radicular Cyst:

1.	CollagenIBA 01/01/2012 - "OKC showed principally parallel orientation of collagen fibers in loosely packed stroma in contrast to dentigerous and radicular cyst. " 01/01/2012 - "In OKC, DC and progressive stages of odontogenesis the predominant color of thin collagen fibers birefringence was found to be greenish yellow and in radicular cyst it was orange red whereas thick fibers in OKC showed yellow orange color whereas DC and RC showed orange red color. " 09/01/1988 - "[Pathologic morphology of collagen fibers in the radicular cyst. " 04/01/2014 - "Two patients who had a radicular cyst or apical periodontitis consented to participate in our clinical study, and OCP/collagen was implanted into the defects after operation. " 04/01/2011 - "Different patterns of radicular cysts suggest different biological behavior and a positive role of inflammation on polarization color of collagen fibers."
2.	Proliferating Cell Nuclear Antigen (PCNA)IBA 05/01/2008 - "The patterns of p53 and PCNA expression in dentigerous and radicular cysts were similar although the two lesions are of different origin. " 05/01/2008 - "PCNA expression was significantly greater in the basal layer of radicular cysts and in the suprabasal layer of odontogenic keratocysts; the percentage of p53 positive cells was significantly greater in the suprabasal layer of odontogenic keratocysts. " 07/01/2014 - "The aim of this study is to assess and compare the expression of p53 and PCNA in lining epithelium of odontogenic keratocyst (OKC) and periapical cyst (PA). " 07/01/2014 - "Immunohistochemical study of p53 and proliferating cell nuclear antigen expression in odontogenic keratocyst and periapical cyst." 10/01/2005 - "(1) To investigate the use of p53, Ki67, and PCNA as an aid in the diagnosis of glandular odontogenic cyst (GOC); (2) To compare the expression of these markers in GOC, low-grade mucoepidermoid carcinoma (MEPCa), and radicular cyst with mucous metaplasia (RCM) as an aid in the differential diagnosis; (3) To establish guidelines for the diagnosis of GOC. "
3.	Plasminogen Activator Inhibitor 1IBA 03/01/2004 - "Moreover, significantly greater t-PA as well as PAI-1 expression was noted in radicular cysts with high levels of inflammation as compared to tissues with low levels of inflammatory cell infiltrates (P < 0.05). " 03/01/2004 - "In addition, this study further shows the tissue localization of the antigens for t-PA as well as PAI-1, and demonstrates that the expression of both t-PA and PAI-1 increases with the grade of inflammation in radicular cysts."
4.	AntibodiesIBA 08/01/1987 - "Antibodies PKK1, KM 4.62 and KS 8.12 gave a heterogeneous staining in follicular and radicular cysts. " 08/01/2013 - "Twenty periapical granulomas (PGs), 20 radicular cysts (RCs), and 20 residual radicular cysts (RRCs) were submitted to immunohistochemical analysis using anti-IL-17, anti-TGF-β1, and anti-FoxP3 antibodies. " 08/01/1987 - "KA5 and KK 8.60 antibodies, reacting exclusively with keratinizing epithelia, including normal gingiva, gave no reaction in radicular cysts, keratocysts and ameloblastoma. " 07/01/2013 - "The three antibodies were detected in connective tissue fibroblasts of all radicular cysts; TRAIL and DR5 immunoexpression was significantly greater (P < 0.05) compared with that of caspase-3. " 01/01/2013 - "Thirty-four cases of radicular cysts were evaluated by immunohistochemistry, using antibodies against B- and T-cell antigens (CD20, CD3, CD4, CD8) and against the endothelial cell marker CD34. "
5.	Caspase 3 (Caspase-3)IBA 07/01/2013 - "The involvement of apoptosis in the pathogenesis of radicular cysts, demonstrated by the immunoexpression patterns of TRAIL, DR5 and caspase-3 in lining epithelium and connective tissue, may explain their bland clinical aggressiveness and slow, benign evolution." 03/01/2010 - "Twenty-six surgical specimens including keratocyst odontogenic tumor (KCOT; n=11), ameloblastoma (AB; n=8) and radicular cysts (RC; n=7) were examined for expression of MMP-2 and caspase-3 using the immunohistochemical method. " 07/01/2013 - "The three antibodies were detected in connective tissue fibroblasts of all radicular cysts; TRAIL and DR5 immunoexpression was significantly greater (P < 0.05) compared with that of caspase-3. " 03/01/2010 - "Keratocystic odontogenic tumor (KCOT) - Ameloblastoma (AB) - Radicular cyst (RC) - Matrix metalloproteinase-2 (MMP-2) - Caspase-3." 07/01/2013 - "Fifteen radicular cysts were fixed in formalin, embedded in paraffin wax and processed for immunohistochemistry to evaluate the expression of polyclonal antibodies against Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL), DR5 and caspase-3. "
6.	Collagen Type I (Type I Collagen)IBA 07/01/2013 - "The authors describe the treatment of an abscessed apical periodontal cyst and show good outcomes of bone healing, using tissue engineering, as collagen type I matrix. " 09/01/2006 - "TGF-beta2 may play a role in the production of type I collagen, which acts as a template for pathologic new bone formation, in radicular cysts." 09/01/2006 - "Signals for type I collagen were immunolocalized in the dense collagen fibers in the cyst walls and in the matrix of the fibrous bone around the radicular cysts, whereas no signals were seen on the inner portions with inflammatory cell infiltration of the cyst walls. "
7.	Durapatite (Hydroxylapatite)IBA 01/01/1995 - "One-year follow-up of 20 patients with radicular cysts and 16 ones with medium-severity chronic periodontitis demonstrated the efficacy of hydroxylapatite with collagen. " 01/01/1995 - "[A clinical x-ray evaluation of the efficacy of hydroxyapatite with collagen in treating periodontitis and radicular cysts]." 06/01/2004 - "To observe the clinical effect of using the domestic BME-10X medical collagen membrane and hydroxyapatite (HA) in guide tissue regeneration of the bone defects caused by periodontitis and periapical cyst. "
8.	CytokinesIBA 08/01/2004 - "In this study, to examine the relationship between radicular cysts and inflammatory cytokines, it was found that there was notable unique evidence on cytokine synthesis from fibroblasts isolated from radicular cysts. " 09/01/1998 - "Furthermore, the biological activity of the contents of radicular cysts (RCC) has been assayed by adding extracts of RCC to cultured human gingival fibroblasts (HGFs) and analyzing the culture medium for the release of inflammatory cytokines. " 01/01/2008 - "The aim of this study was to compare the cytokine expression profiles of cyst fluids (CFs) and tissue culture supernatants (SUPs) from 7 radicular cysts (RCs) and 7 odontogenic keratocysts (OKCs) by using Human Cytokine Antibody Array to identify the specific cytokines involved in formation and expansion of RCs and OKCs, respectively. " 03/01/2010 - "Distinct Th1, Th2 and Treg cytokines balance in chronic periapical granulomas and radicular cysts." 01/01/2014 - "Several cytokines participate in the mechanisms of inflammation, tissue repair, and bone resorption associated with periapical cysts. "
9.	Interleukin-6 (Interleukin 6)IBA 01/01/2014 - "The aim of the present study was to evaluate the distribution of mast cells and macrophages and the expression of interleukin-6 (IL-6) in periapical cysts. " 01/01/2014 - "Distribution of mast cells and macrophages and expression of interleukin-6 in periapical cysts." 08/01/2004 - "From these results, it was suggested that fibroblasts inducing IL-6 production might play important roles in the expansion of radicular cysts. " 08/01/2004 - "High IL-6 synthesis in cultured fibroblasts isolated from radicular cysts." 01/01/2014 - "The results reinforced the participation of mast cells and macrophages in the pathogenesis of periapical cysts and suggested that IL-6 is not the major bone resorption mediator in larger periapical cysts."
10.	Formaldehyde (Formol)FDA Link 12/01/1979 - "Material for the study of this phenomenon consisted of radicular cysts fixed in formol saline. " 03/01/2004 - "Thirty formalin-fixed, paraffin-embedded specimens of radicular cysts were examined using immunohistochemistry. " 02/01/2011 - "Immunohistochemistry was carried out on 55 formalin-fixed and paraffin-embedded, well-defined periapical cysts with minimum inflammation, obtained from the archival tissue database of the Department of Oral Pathology and Surgery. " 01/01/2015 - "Our study covered 90 formalin fixed paraffin embedded tissue samples: 26 primary cases each of radicular cysts (RC), dentigerous cysts (DC) and odontogenic keratocysts (OKC) and 12 of recurrent OKCs. " 03/01/2011 - "The material for the study included 51 formalin-fixed paraffin-embedded tissue blocks (15 odontogenic keratocyst, 15 dentigerous cysts, 15 radicular cysts and four normal mucosa and two dental follicular tissue as controls), retrieved from the Department of Oral Pathology and Microbiology, MCODS, Manipal. "

Therapies and Procedures

1.	Decompression 07/01/2015 - "Decompression with subsequent enucleation proved to be effective treatment of large radicular cyst in maxillary sinus with low-morbidity." 07/01/2015 - "Decompression as an effective primary approach to large radicular cyst in the maxillary sinus--A case report." 04/01/2015 - "Treatment of a large radicular cyst-enucleation or decompression?" 02/01/2014 - "The treatment of radicular cysts includes conventional nonsurgical root canal therapy when lesion is localized or surgical treatment like enucleation, marsupialization or decompression when lesion is large. " 02/01/2009 - "With decompression of cyst cavities or overfilling of the root canals, non-surgical treatment of radicular cyst is a simple, economical, safe, and effective treatment modality."
2.	Curettage 12/01/1996 - "Considering this, together with the difficulty involved in the clinical diagnosis of radicular cysts, curettage of the cyst wall and drainage may be more effective for facilitating the healing process than use of marsupialization alone." 08/01/2008 - "Seventy biopsies obtained during periapical surgery were histologically analyzed following curettage of the tissue, establishing the diagnosis as either apical granuloma, radicular cyst, or scar tissue. "
3.	Epidural Blood Patch 03/18/2014 - "Though initially planned, epidural blood patch and surgical treatment of the radicular cyst were not performed because clinical and radiologic findings improved with hematoma drainage, bed rest, and hydration. "
4.	Bed Rest (Bedrest) 03/18/2014 - "Though initially planned, epidural blood patch and surgical treatment of the radicular cyst were not performed because clinical and radiologic findings improved with hematoma drainage, bed rest, and hydration. "
5.	Oral Pathology 03/01/2015 - "A total of 30 cases and out of which 15 of periapical granuloma and 15 radicular cyst, each along with the case details from the previously diagnosed cases in the department of oral pathology were selected for the study. " 12/01/2014 - "Histopathology records of PLs diagnosed from January 1990 to December 2012 at the Department of Oral Pathology, University College Hospital Ibadan, were examined and categorized into periapical cysts (PCs); periapical granuloma (PGs) and others. " 08/01/2014 - "Eighteen radicular cysts (RCs) and 22 periapical granulomas (PGs) were collected in the Department of Oral Pathology after periapical surgery as the experimental samples. " 02/01/2011 - "Immunohistochemistry was carried out on 55 formalin-fixed and paraffin-embedded, well-defined periapical cysts with minimum inflammation, obtained from the archival tissue database of the Department of Oral Pathology and Surgery. " 03/01/2011 - "The material for the study included 51 formalin-fixed paraffin-embedded tissue blocks (15 odontogenic keratocyst, 15 dentigerous cysts, 15 radicular cysts and four normal mucosa and two dental follicular tissue as controls), retrieved from the Department of Oral Pathology and Microbiology, MCODS, Manipal. "