Keeping it quiet: chromatin control of gammaherpesvirus latency.

Abstract	The human gammaherpesviruses Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV) establish long-term latent infections associated with diverse human cancers. Viral oncogenesis depends on the ability of the latent viral genome to persist in host nuclei as episomes that express a restricted yet dynamic pattern of viral genes. Multiple epigenetic events control viral episome generation and maintenance. This Review highlights some of the recent findings on the role of chromatin assembly, histone and DNA modifications, and higher-order chromosome structures that enable gammaherpesviruses to establish stable latent infections that mediate viral pathogenesis.
Authors	Paul M Lieberman
Journal	Nature reviews. Microbiology (Nat Rev Microbiol) Vol. 11 Issue 12 Pg. 863-75 (Dec 2013) ISSN: 1740-1534 [Electronic] England
PMID	24192651 (Publication Type: Journal Article, Review)
Chemical References	Chromatin Histones DNA
Topics	Chromatin (metabolism) DNA (metabolism) Epigenesis, Genetic Gene Expression Regulation Herpesvirus 4, Human (genetics, physiology) Herpesvirus 8, Human (genetics, physiology) Histones (metabolism) Host-Pathogen Interactions Humans Protein Processing, Post-Translational Virus Latency

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