Abstract | BACKGROUND: METHODS: RESULTS: Apical membranous distribution of ezrin protein was only observed in normal cervical glands, while perinuclear staining was only observed in cervical cancers. Strong cytoplasmic and diffuse localization of ezrin were frequently seen in the cervical cancers compared with the normal counterparts. Furthermore, this strongly positive ezrin expression was significantly higher in cervical cancers than in CIN, CGIN, and normal cervical epithelia. Ezrin overexpression was closely related with poor differentiation, late stage, and lymph node metastasis. Additionally, ezrin overexpression was associated with lower 10-year survival rate for patients with early stage cervical cancer, but not for patients with advanced stage. CONCLUSIONS:
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Authors | Jienan Kong, Yan Li, Shuangping Liu, Haidan Jin, Yongjun Shang, Chengshi Quan, Yulin Li, Zhenhua Lin |
Journal | BMC cancer
(BMC Cancer)
Vol. 13
Pg. 520
(Nov 04 2013)
ISSN: 1471-2407 [Electronic] England |
PMID | 24182314
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cytoskeletal Proteins
- ezrin
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Topics |
- Adult
- Aged
- Cytoskeletal Proteins
(genetics, metabolism)
- Female
- Gene Expression
- Humans
- Immunohistochemistry
- Lymphatic Metastasis
- Middle Aged
- Neoplasm Grading
- Neoplasm Staging
- Papillomaviridae
(physiology)
- Papillomavirus Infections
(virology)
- Prognosis
- Protein Transport
- Uterine Cervical Neoplasms
(genetics, metabolism, mortality, pathology, virology)
- Young Adult
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