The present study was carried out to evaluate antiarthritic potential and
phytochemical screening of various extracts of Ficus lacor aerial roots. The antiarthritic activity was evaluated by adjuvant-induced
arthritis at the dose of 50 and 100 mg/kg
body weight and the standard
drug used was
indomethacin. The extracts administered in higher doses reduced the lesions to a greater extent showing a dose-dependent decrease in lesions comparable with standard
drug indomethacin. The extracts of
FLPE and FLET showed significant increase in
body weight as compared to arthritic control group as well as an increase in liver weight, a decrease in liver weight, and an increase in spleen weight in
arthritis control. The extracts of
FLPE and FLET showed significant decrease in WBC count, increase in
hemoglobin contents, and RBC count as compared to control group. FLEA and FLCF were not able to produce a significant effect. There was significant reduction in production of
IL-1 and TNF- α level between model group and control group in serum. In conclusion, we demonstrate that, at 100 mg/kg
body weight, doses of
FLPE and PLET extracts were highly effective in preventing and suppressing the development of adjuvant-induced
arthritis.