Abstract | BACKGROUND: The systemic administration of theophylline is useful for asthma treatment. However its narrow therapeutic range makes it difficult to use. Little is known about its potential in inhalation therapy, particularly repeated inhalation. OBJECTIVE: The purpose of this study is to investigate the therapeutic usefulness of inhaled aminophylline in an asthma model. METHODS: RESULTS:
Aminophylline relaxed the ACh-induced contraction of tracheal smooth muscle in vitro in a concentration-dependent manner. Pretreatment with single-dose aminophylline inhalation suppressed OVA-induced airway constriction to the same extent as the intraperitoneal pretreatment with high-dose aminophylline (10-20 mg/kg). However, pretreatment with single-dose aminophylline inhalation did not suppress eosinophil infiltration into airways (neither bronchoalveolar lavage [BAL] fluid nor lung tissue) and did not suppress airway hyperreactivity to ACh, 24 h after OVA challenge. Repeated inhalation of aminophylline (twice daily for 7 days) suppressed the infiltration of eosinophils and suppressed airway hypersensitivity to ACh. In addition, high concentrations of aminophylline inhibited production of oxygen radicals by BAL cells. CONCLUSION:
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Authors | Masato Muraki, Shota Wada, Takeshi Ohno, Souichirou Hanada, Hirochiyo Sawaguchi, Takashi Iwanaga, Hiroaki Kume, Yuji Tohda |
Journal | Drug delivery
(Drug Deliv)
Vol. 21
Issue 5
Pg. 321-7
(Aug 2014)
ISSN: 1521-0464 [Electronic] England |
PMID | 24148015
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Administration, Inhalation
- Aminophylline
(pharmacology)
- Animals
- Asthma
(drug therapy)
- Bronchoalveolar Lavage Fluid
(chemistry)
- Bronchoconstriction
(drug effects)
- Eosinophils
(drug effects)
- Guinea Pigs
- Inflammation
(chemically induced, drug therapy)
- Lung
(drug effects)
- Male
- Ovalbumin
(pharmacology)
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