Abstract | BACKGROUND: Patients with chronic rhinosinusitis (CRS) exhibit centrally mediated behavioral changes commonly referred to as "sickness behavior." Sleep alteration is a component of sickness behavior which is estimated to affect up to 70 million patients annually. Patients with CRS have poor sleep quality, and little is known about the underlying etiology and pathophysiology. This narrative review aims to further organize and present the current knowledge associating sleep and CRS. METHODS: RESULTS: CONCLUSION: Patients with CRS have sleep dysfunction that is associated with their disease severity and overall quality of life. The etiology of sleep dysfunction in CRS is most likely multifactorial. Increasing evidence suggests sleep dysfunction in patients with CRS is partly due to the inflammatory disease process, and sleep physiology in patients with CRS may be actively regulated by the inflammatory component of the disease.
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Authors | Jeremiah A Alt, Timothy L Smith |
Journal | International forum of allergy & rhinology
(Int Forum Allergy Rhinol)
Vol. 3
Issue 11
Pg. 941-9
(Nov 2013)
ISSN: 2042-6984 [Electronic] United States |
PMID | 24039230
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
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Copyright | © 2013 ARS-AAOA, LLC. |
Chemical References |
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Topics |
- Chronic Disease
- Cytokines
(metabolism)
- Fatigue
(complications)
- Humans
- Nasal Obstruction
(complications)
- Rhinitis
(complications, physiopathology)
- Sinusitis
(complications, physiopathology)
- Sleep Wake Disorders
(complications, physiopathology)
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