COX-2, TFF1, and Src define better prognosis in young patients with gastric cancer.

Abstract

BACKGROUND AND OBJECTIVES:

Despite its dwindling occurrence, gastric cancer remains a leading cause of cancer related mortality worldwide. Molecular determinants of prognosis that impact survival are being sought out as a means to facilitate rational clinical decision-making and enhance patient management. In this study, we evaluated three molecules implicated in gastric carcinogenesis and demonstrated that the differential expression of cyclooxygenase-2 (COX-2) and the viral oncogene homolog Src proteins could explain the differences in survival observed in patients older and younger than 50 years of age.

METHODS:

We evaluated 5-year survival in a cohort of 423 gastric cancer patients using chronological age as a variable. Additionally, we assessed the protein expression of three molecules (COX-2, TFF1, Src) implicated in the pathogenesis of gastric cancer using immunohistochemistry.

RESULTS:

We found that patients younger than 50 years of age had a better 5-year survival rate in all tumor stages. We found that the expression of COX-2 and Src correlated significantly with survival in this group without any significant impact attributable to TFF1.

CONCLUSIONS:

Our study demonstrates that young gastric cancer patients have a better prognostic outlook that could in part be explained by the differential expression of COX-2 and Src.

• Authors: Claus Schildberg, M Abbas, S Merkel, A Agaimy, A Dimmler, A Schlabrakowski, R Croner, J Leupolt, W Hohenberger, H Allgayer
• Journal: Journal of surgical oncology (J Surg Oncol) Vol. 108 Issue 6 Pg. 409-13 (Nov 2013) ISSN: 1096-9098 [Electronic] United States
• PMID: 24037722 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2013 Wiley Periodicals, Inc.

Chemical References

• Biomarkers, Tumor
• TFF1 protein, human
• Trefoil Factor-1
• Tumor Suppressor Proteins
• Cyclooxygenase 2
• PTGS2 protein, human
• Proto-Oncogene Proteins pp60(c-src)

Topics

• Adult
• Age Factors
• Biomarkers, Tumor (analysis)
• Carcinoma (chemistry, mortality, pathology, surgery)
• Cyclooxygenase 2 (analysis)
• Esophagogastric Junction
• Female
• Germany
• Humans
• Immunohistochemistry
• Kaplan-Meier Estimate
• Male
• Middle Aged
• Neoplasm Grading
• Neoplasm Staging
• Predictive Value of Tests
• Prognosis
• Prospective Studies
• Proto-Oncogene Proteins pp60(c-src) (analysis)
• Retrospective Studies
• Stomach Neoplasms (chemistry, mortality, pathology, surgery)
• Tissue Array Analysis
• Trefoil Factor-1
• Tumor Suppressor Proteins (analysis)