5-lipoxygenase mRNA and protein isoforms.

Abstract

5-Lipoxygenase (5-LO) catalyses the two initial steps in the biosynthesis of leukotrienes, a group of inflammatory lipid mediators derived from arachidonic acid. An increased level of leukotrienes is associated with chronic inflammatory diseases such as asthma or atherosclerosis. In this MiniReview, we focus on recent findings regarding alternative splice variants of 5-LO with a special emphasis on two potential protein isoforms expressed in human B-lymphocytes which might be of interest as new drug targets.

• Authors: Meike J Ochs, Beatrix Suess, Dieter Steinhilber
• Journal: Basic & clinical pharmacology & toxicology (Basic Clin Pharmacol Toxicol) Vol. 114 Issue 1 Pg. 78-82 (Jan 2014) ISSN: 1742-7843 [Electronic] England
• PMID: 24020397 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: © 2013 Nordic Pharmacological Society. Published by John Wiley & Sons Ltd.

Chemical References

• Leukotrienes
• Protein Isoforms
• Proteome
• RNA, Messenger
• Arachidonate 5-Lipoxygenase

Topics

• Arachidonate 5-Lipoxygenase (genetics, metabolism)
• B-Lymphocytes (metabolism)
• Gene Expression Regulation, Enzymologic
• Humans
• Leukotrienes (metabolism)
• Protein Isoforms (genetics, metabolism)
• Proteome (genetics, metabolism)
• RNA, Messenger (genetics, metabolism)