Abstract | BACKGROUND: The Human Immunodeficiency Virus (HIV) and the Tuberculosis (TB) co infection are contributory to each other in causing a progressive decline in the cell mediated immunity and a damage to the hepatobiliary system. The aim of our study was to estimate the extent of liver damage which was caused by these infections before the start of the therapy with hepatotoxic drugs like Antiretroviral Therapy (ART) and Antitubercular Drugs (ATD). METHODS: One hundred and ninty three confirmed HIV positive cases were enrolled in this study. The cases were divided into 2 groups; Group 1-100 subjects with TB and Group 2-93 subjects without TB.80 age and sex matched controls were also included (Group 0). Some parameters of the serum Liver Function Test (LFT) were estimated biochemically by using an auto analyzer (ERBA XL600,Transasia). RESULTS: CONCLUSION: The results have shown the importance of estimating some LFT parameters, prior to the start of ATD and ART in these cases. Hence, a mandatory performance of LFT is recommended, as it is simple and cost effective.
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Authors | Subir Kumar Dey, Indranath Ghosh, Debojyoti Bhattacharjee, Praveen A, Sumanta Jha, Anindya Dasgupta, Sukanta Kumar Dey |
Journal | Journal of clinical and diagnostic research : JCDR
(J Clin Diagn Res)
Vol. 7
Issue 6
Pg. 1068-72
(Jun 2013)
ISSN: 2249-782X [Print] India |
PMID | 23905105
(Publication Type: Journal Article)
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