Abstract | BACKGROUND: METHODS AND RESULTS: FOUR GROUPS WERE STUDIED: sham; myocardial infarction (MI); MI+ribose; MI+CrT-OE+ribose. In a pilot study, ribose given in drinking water was bioavailable, resulting in a two-fold increase in myocardial ribose-5-phosphate levels. However, 8 weeks post-surgery, total adenine nucleotide (TAN) pool was decreased to a similar amount (8-14%) in all infarcted groups irrespective of the treatment received. All infarcted groups also presented with a similar and substantial degree of left ventricular ( LV) dysfunction (3-fold reduction in ejection fraction) and LV hypertrophy (32-47% increased mass). Ejection fraction closely correlated with infarct size independently of treatment (r(2) = 0.63, p<0.0001), but did not correlate with myocardial creatine or TAN levels. CONCLUSION: Elevating myocardial ribose and creatine levels failed to maintain TAN pool or improve post- infarction LV remodeling and function. This suggests that ribose is not rate-limiting for purine nucleotide biosynthesis in the chronically failing mouse heart and that alternative strategies to preserve TAN pool should be investigated.
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Authors | Kiterie M E Faller, Debra J Medway, Dunja Aksentijevic, Liam Sebag-Montefiore, Jürgen E Schneider, Craig A Lygate, Stefan Neubauer |
Journal | PloS one
(PLoS One)
Vol. 8
Issue 6
Pg. e66461
( 2013)
ISSN: 1932-6203 [Electronic] United States |
PMID | 23823183
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adenine Nucleotides
- Ribose
- Creatinine
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Topics |
- Adenine Nucleotides
(metabolism)
- Animals
- Creatinine
(metabolism)
- Heart Failure
(metabolism, physiopathology)
- Heart Function Tests
- Mice
- Mice, Transgenic
- Myocardium
(metabolism)
- Pilot Projects
- Ribose
(administration & dosage)
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