Interleukin-10 -592C/A, -819C/T and -1082A/G Polymorphisms with Risk of Type 2 Diabetes Mellitus: A HuGE Review and Meta-analysis.

Abstract

BACKGROUND:

Several studies have been conducted in recent years to evaluate the risk of type 2 diabetes mellitus (T2DM) and polymorphisms of interleukin (IL)-10. However, the results remain conflicting rather than conclusive. This meta-analysis aimed to summarize the current evidence from case-control studies that evaluated this association.

METHODS:

We carried out a search in Medline, EMBASE, and the Chinese National Knowledge Infrastructure (CNKI) database for relevant studies. Data were extracted using a standardized form and pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the strength of the association.

RESULTS:

10 studies were included in our meta-analysis and systemic review. Our meta-analysis indicated that IL-10 -1082A/G polymorphism was associated with the risk of T2DM (GA vs. AA: OR = 1.21, 95% CI = 1.03-1.14; GA/GG vs. AA: OR = 1.22, 95% CI = 1.05-1.41), whereas there was no association between IL-10 -592C/A (CC/CA vs. AA: OR = 1.07, 95% CI = 0.59-1.93) or -819C/T (CC/CT vs. TT: OR = 0.93, 95% CI = 0.49-1.75) polymorphism and T2DM risk was found in our study.

CONCLUSIONS:

This meta-analysis provides strong evidence that IL-10 -1082A/G polymorphism associated with risk of T2DM. However, no association of the IL-10 -592C/A or -819C/T polymorphism with T2DM risk was found. Additional well-designed large studies were required for the validation of our results.

• Authors: Yanyin Hua, Jie Shen, Yingxiang Song, Yubo Xing, Xiao Ye
• Journal: PloS one (PLoS One) Vol. 8 Issue 6 Pg. e66568 ( 2013) ISSN: 1932-6203 [Electronic] United States
• PMID: 23805237 (Publication Type: Journal Article, Meta-Analysis, Review)

Chemical References

• IL10 protein, human
• Interleukin-10

Topics

• Diabetes Mellitus, Type 2 (genetics)
• Female
• Genetic Predisposition to Disease
• Humans
• Interleukin-10 (genetics)
• Male
• Polymorphism, Genetic
• Risk Factors