Primary Fallopian tube
carcinoma (PFTC) is a rare but highly aggressive disease. Currently, treatments are similar to those used in
epithelial ovarian carcinoma (EOC), however, there are distinct differences between the two diseases. PFTC tends to recur in the retroperitoneal nodes and distant sites more often than EOC. Limited literature with regard to effective agents in
platinum-resistant and -refractory (Pt-R) disease exists, particularly after two lines of consecutive treatment. In this case report, a 47-year-old female with PFTC exhibited recurrence in the liver after postoperative
chemotherapy. The patient received
paclitaxel and
cisplatin combination as first-line
chemotherapy and
topotecan as a second-line treatment, which is considered
platinum-refractory. After the second-line treatment failed, this patient received a
gemcitabine plus
cisplatin combination as third-line
chemotherapy for a total of 6 cycles. The liver
metastases regressed rapidly and completely. The patient's progression-free survival (PFS) was 10 months and overall survival (OS) was 45 months. In conclusion,
gemcitabine and
cisplatin combination is an effective regimen for refractory PFTC even after the failure of two previous lines of consecutive
chemotherapy and this warrants further independent investigation.