Abstract | INTRODUCTION: METHODS: RESULTS: Thirty-nine (25.6%) patients in the control group and 33 (28.2) ACHD patients (2 hypoxemic and 31 nonhypoxemic) had a Lp(a) concentration higher than 30 mg/dL. No significant differences were seen between patients with Lp(a) concentration ≤30 or >30 mg/dL after performing a binary logistic regression multivariate analysis including as covariates all the variables that showed significance (P < .001) between the case and control groups (age, gender, CRP, and total, LDL, and high-density lipoprotein cholesterol) besides being congenital or not. Similarly, no significant differences were found between ACHD patients with Lp(a) concentration lower and higher than 30 mg/dL after performing a multivariate analysis in which age, sex, body mass index, LDL-cholesterol levels, and being or not hypoxemic were included as covariates. Pearson's correlation showed a significant positive correlation (0.27) between LDL-cholesterol and Lp(a) concentrations (P = .004) and between CRP and N-terminal-pro- B-type natriuretic peptide levels (0.19) in ACHD patients (P = .035). CONCLUSION:
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Authors | Efrén Martínez-Quintana, Fayna Rodríguez-González |
Journal | Congenital heart disease
(Congenit Heart Dis)
2014 Jan-Feb
Vol. 9
Issue 1
Pg. 63-8
ISSN: 1747-0803 [Electronic] United States |
PMID | 23701863
(Publication Type: Comparative Study, Journal Article)
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Copyright | © 2013 Wiley Periodicals, Inc. |
Chemical References |
- Biomarkers
- Cholesterol, HDL
- Cholesterol, LDL
- Lipoprotein(a)
- Peptide Fragments
- Triglycerides
- pro-brain natriuretic peptide (1-76)
- Natriuretic Peptide, Brain
- C-Reactive Protein
- Cholesterol
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Topics |
- Adult
- Age Factors
- Biomarkers
(blood)
- C-Reactive Protein
(analysis)
- Case-Control Studies
- Chi-Square Distribution
- Cholesterol
(blood)
- Cholesterol, HDL
(blood)
- Cholesterol, LDL
(blood)
- Female
- Heart Defects, Congenital
(blood)
- Humans
- Lipoprotein(a)
(blood)
- Logistic Models
- Male
- Multivariate Analysis
- Natriuretic Peptide, Brain
(blood)
- Peptide Fragments
(blood)
- Triglycerides
(blood)
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