[Three cases of ATP-induced bronchospasm during thoracic endovascular aortic repair].

Abstract

We report three cases (73-year-old, 69-year-old and 76-year-old men) of bronchospasm induced by adenosine triphosphate (ATP) during thoracic endovascular aortic repair (TEVAR). Severe broncospasm occurred soon after administration of ATP to obtain transient asystole during TEVAR. All three cases were complicated with asthma or chronic obstructive pulmonary disease (COPD) before TEVAR, and airway hyper-reactivity was suspected. One case (73-year-old) required postoperative intensive care to treat bronchospasm, and the other two cases recovered during the operation. The possible mechanism of adenosine-induced bronchoconstriction is selective interaction with active mast cells with subsequent release of preformed and newly formed mediators. Careful attention should be paid when ATP is injected during TEVAR in patients with asthma or COPD.

• Authors: Yukimasa Takada, Toshiya Kawagishi, Natsumi Kii, Misako Higuchi, Masanori Yamauchi, Michiaki Yamakage
• Journal: Masui. The Japanese journal of anesthesiology (Masui) Vol. 62 Issue 4 Pg. 402-5 (Apr 2013) ISSN: 0021-4892 [Print] Japan
• PMID: 23697189 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Adenosine Triphosphate

Topics

• Adenosine Triphosphate (administration & dosage, adverse effects)
• Aged
• Aortic Aneurysm, Thoracic (therapy)
• Asthma (complications)
• Bronchial Spasm (chemically induced)
• Humans
• Injections, Intravenous
• Male
• Pulmonary Disease, Chronic Obstructive (complications)
• Stents