Effects of procoagulants on wound healing.

Abstract

As blood coagulation is a prelude for wound healing, a systemic haemocoagulant (Botropase) and local procoagulants (thrombin and fibrin) were evaluated on physical (wound breaking strength, wound half-closure time and period of epithelization), biochemical (granuloma-hydroxyproline and hexosamine) and histological attributes of healing wounds in albino rats. Botropase prompted all phases of tissue repair. Thrombin delayed wound contraction whereas fibrin had no discernable action. The findings that procoagulants modify healing process has bearing on their surgical use.

• Authors: K V Ramesh, C M Rao, K L Bairy, K Ramanarayan, D R Kulkarni
• Journal: Indian journal of experimental biology (Indian J Exp Biol) Vol. 28 Issue 1 Pg. 43-5 (Jan 1990) ISSN: 0019-5189 [Print] India
• PMID: 2365407 (Publication Type: Journal Article)

Chemical References

• Coagulants
• Enzymes
• botropase
• Fibrin
• Thrombin

Topics

• Animals
• Coagulants (pharmacology)
• Enzymes (pharmacology)
• Female
• Fibrin (pharmacology)
• Male
• Rats
• Rats, Inbred Strains
• Thrombin (pharmacology)
• Wound Healing (drug effects)