Abstract | BACKGROUND: RESULTS: In this study, we showed that OX40 was specifically expressed in CD4+ T cells naturally infected with HTLV-1 that have the potential to produce pro-inflammatory cytokines along with Tax expression. We also showed that OX40 was overexpressed in spinal cord infiltrating mononuclear cells in a clinically progressive HAM/TSP patient with a short duration of illness. The levels of the soluble form of OX40 (sOX40) in the cerebrospinal fluid (CSF) from chronic progressive HAM/TSP patients or from patients with other inflammatory neurological diseases (OINDs) were not different. In contrast, sOX40 levels in the CSF of rapidly progressing HAM/TSP patients were higher than those in the CSF from patients with OINDs, and these patients showed higher sOX40 levels in the CSF than in the plasma. When our newly produced monoclonal antibody against OX40 was added to peripheral blood mononuclear cells in culture, HTLV-1-infected T cells were specifically removed by a mechanism that depends on antibody-dependent cellular cytotoxicity. CONCLUSIONS: Our study identified OX40 as a key molecule and biomarker for rapid progression of HAM/TSP. Furthermore, blocking OX40 may have potential in therapeutic intervention for HAM/TSP.
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Authors | Mineki Saito, Reiko Tanaka, Shiho Arishima, Toshio Matsuzaki, Satoshi Ishihara, Takashi Tokashiki, Yusuke Ohya, Hiroshi Takashima, Fujio Umehara, Shuji Izumo, Yuetsu Tanaka |
Journal | Retrovirology
(Retrovirology)
Vol. 10
Pg. 51
(May 07 2013)
ISSN: 1742-4690 [Electronic] England |
PMID | 23651542
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Receptors, OX40
- TNFRSF4 protein, human
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Animals
- Biomarkers
(cerebrospinal fluid)
- Cerebrospinal Fluid
(chemistry)
- Disease Progression
- Female
- Gene Expression
- Human T-lymphotropic virus 1
(pathogenicity)
- Humans
- Male
- Middle Aged
- Paraparesis, Tropical Spastic
(pathology)
- Receptors, OX40
(analysis)
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