Abstract | BACKGROUND: OBJECTIVE: The goal of this study was to analyze the effect of PE on clinically active radiologic lesions in steroid-refractory relapses of MS and idiopathic inflammatory demyelinating diseases of the central nervous system. METHODS: This was a prospective, observational pilot study in which the primary end point was the degree of radiologic resolution of active lesions after PE. RESULTS: A total of 15 patients were included (median age, 36.9 years [age range, 21-67 years]; 60% women). Five (33.3%) of the 15 patients had relapsing-remitting MS, 2 (13.3%) had clinically isolated syndrome that presented with transverse myelitis, 2 (13.3%) had recurrent myelitis, 1 (6.7%) had transverse myelitis, 1 (6.7%) had longitudinally extensive transverse myelitis, 1 (6.7%) had acute disseminated encephalomyelitis, 1 (6.7%) had Baló's concentric sclerosis, and 2 (13.3%) had neuromyelitis optica. Mean increase on the expanded disability status scale scores due to relapses was 4.8 (2.53). After PE, 93.3% showed a marked to moderate clinical improvement, and 46.7% recovered their baseline expanded disability status scale score 3 months post-PE. On the post-PE MRI, 60% showed radiologic resolution (80% mass-effect lesions, 83.3% new-onset disease, and 100% neuromyelitis optica), 20% had partial resolution, and 20% no resolution. A significant relationship was not obtained between degree of resolution of radiologic lesions and the variables: clinical response to PE, new-onset disease, mass-effect lesions, number of PE sessions, and early initiation of PE. CONCLUSION: A marked to moderate clinical improvement post-PE accompanied by a lack of radiologic resolution of the active lesion is not indicative of poor prognosis.
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Authors | Jose E Meca-Lallana, Rocío Hernández-Clares, Adelaida León-Hernández, Alicia Genovés Aleixandre, Margarita Cacho Pérez, Jose J Martín-Fernández |
Journal | Clinical therapeutics
(Clin Ther)
Vol. 35
Issue 4
Pg. 474-85
(Apr 2013)
ISSN: 1879-114X [Electronic] United States |
PMID | 23541130
(Publication Type: Journal Article)
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Copyright | Copyright © 2013 Elsevier HS Journals, Inc. All rights reserved. |
Topics |
- Adult
- Aged
- Female
- Humans
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Multiple Sclerosis
(physiopathology, therapy)
- Pilot Projects
- Plasma Exchange
- Recurrence
- Young Adult
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