Abstract | OBJECTIVE: METHODS: The expression of GRHPR in tissues and cells was detected by Western blotting. Immunohistochemistry was utilized to examine the expression patterns of GRHPR and Ki-67 in a surgical cohort of HCC and adjacent liver tissues. RESULTS: We demonstrated that GRHPR showed a lower expression in tumor tissues than in nontumoral tissues. GRHPR was negatively correlated with Ki-67 (R(2) = 0.771, p < 0.05) and GRHPR was reduced in proliferative Huh7 cells (p < 0.05). Patients with negative GRHPR both in tumor tissues and nontumoral tissues had a significantly shorter survival time than those with positive GRHPR (p < 0.001). Multivariate analysis established that GRHPR was detected in nontumoral tissues as an independent prognostic factor for patients with HCC. CONCLUSIONS: Our findings suggest that the GRHPR defect in noncancerous tissues may represent an independent predictor of poor survival for HCC patients after curative resection and that there may be a link between GRHPR and prognosis of HCC patients.
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Authors | Yinglian Pan, Runzhou Ni, Qingchun Deng, Xiaodong Huang, Yixin Zhang, Cuihua Lu, Feifei Li, Da Huang, Song He, Buyou Chen |
Journal | Pathobiology : journal of immunopathology, molecular and cellular biology
(Pathobiology)
Vol. 80
Issue 3
Pg. 155-62
( 2013)
ISSN: 1423-0291 [Electronic] Switzerland |
PMID | 23486161
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2013 S. Karger AG, Basel. |
Chemical References |
- Biomarkers, Tumor
- Alcohol Oxidoreductases
- glyoxylate reductase
|
Topics |
- Alcohol Oxidoreductases
(analysis, biosynthesis)
- Biomarkers, Tumor
(analysis)
- Blotting, Western
- Carcinoma, Hepatocellular
(enzymology, mortality, pathology)
- Disease-Free Survival
- Female
- Hepatectomy
- Humans
- Immunohistochemistry
- Kaplan-Meier Estimate
- Liver Neoplasms
(enzymology, mortality, pathology)
- Male
- Middle Aged
- Prognosis
- Tissue Array Analysis
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