glyoxylate reductase

the human gene encodes an enzyme with hydroxypyruvate reductase, glyoxylate reductase, and D-glycerate dehydrogenase enzymatic activities. The enzyme has widespread tissue expression and has a role in metabolism. Type II hyperoxaluria is caused by mutations in this gene; RefSeq NM_012203

Also Known As:

Networked: 28 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Holmes, Ross P: 3 articles (10/2012 - 08/2006)
2.	Knight, John: 3 articles (10/2012 - 08/2006)
3.	Rumsby, Gill: 3 articles (06/2009 - 12/2003)
4.	Milliner, D S: 2 articles (01/2018 - 01/2001)
5.	Milliner, Dawn S: 2 articles (10/2012 - 08/2006)
6.	Cramer, Scott D: 2 articles (03/2012 - 08/2006)
7.	Abid, Aiysha: 1 article (08/2022)
8.	Hashmi, Seema: 1 article (08/2022)
9.	Lanewala, Ali Asghar: 1 article (08/2022)
10.	Shekhani, Sualeha Siddiq: 1 article (08/2022)

Related Diseases

1.	Primary hyperoxaluria type 2 08/01/2006 - "Glyoxylate reductase activity in blood mononuclear cells and the diagnosis of primary hyperoxaluria type 2." 12/01/2003 - "Molecular analysis of the glyoxylate reductase (GRHPR) gene and description of mutations underlying primary hyperoxaluria type 2." 11/01/1999 - "The data presented provide a biochemical explanation for the previously observed differences in the tissue distribution of HPR and glyoxylate reductase activities in human subjects and support the claim that diagnoses of primary hyperoxaluria type 2 should be made by measurement of glyoxylate reductase activity in the liver." 10/01/2014 - "The objective of this study was to investigate ethnic differences in the glyoxylate reductase/hydroxypyruvate reductase (GRHPR) gene in patients with primary hyperoxaluria type 2 (PH2). " 01/01/1998 - "Kinetic analysis and tissue distribution of human D-glycerate dehydrogenase/glyoxylate reductase and its relevance to the diagnosis of primary hyperoxaluria type 2."
2.	Primary Hyperoxaluria (Oxaluria, Primary) 10/01/2012 - "4-Hydroxy-2-oxoglutarate aldolase inactivity in primary hyperoxaluria type 3 and glyoxylate reductase inhibition." 06/01/2009 - "The primary hyperoxalurias, PH1 and PH2, are inherited disorders caused by deficiencies of alanine:glyoxylate aminotransferase and glyoxylate reductase, respectively. " 01/01/2018 - "Primary hyperoxaluria Type II and primary hyperoxaluria Type III are due to the deficit of glyoxylate reductase/hydroxypyruvate reductase (GRHPR) and 4-hydroxy-2-oxoglutarate aldolase (HOGA1), respectively. " 01/01/2001 - "The primary hyperoxalurias are autosomal recessive disorders resulting from deficiency of hepatic alanine:glyoxylate aminotransferase (PHI) or D-glycerate dehydrogenase/glyoxylate reductase (PHII). " 01/01/2000 - "Diagnosis of the two best-characterized disorders, primary hyperoxaluria (PH) Types 1 and 2, is achieved by sequential measurement of alanine:glyoxylate aminotransferase and glyoxylate reductase enzyme activity in a single needle liver biopsy. "
3.	Hyperoxaluria (Oxaluria) 07/01/1997 - "The metabolic defect is deficiency of D-glycerate dehydrogenase/glyoxylate reductase leading to characteristic hyperoxaluria and excretion of L-glycerate, the cornerstone of diagnosis of PH 2. Although development of terminal renal failure seems to be less prevalent than in PH 1, recent reports indicate that chronic as well as terminal renal insufficiency may occur. " 01/01/1995 - "PH2 is characterized by hyperoxaluria and L-glyceric aciduria and is caused by deficiency of D-glycerate dehydrogenase/glyoxylate reductase. "
4.	Renal Insufficiency (Renal Failure) 07/01/1997 - "The metabolic defect is deficiency of D-glycerate dehydrogenase/glyoxylate reductase leading to characteristic hyperoxaluria and excretion of L-glycerate, the cornerstone of diagnosis of PH 2. Although development of terminal renal failure seems to be less prevalent than in PH 1, recent reports indicate that chronic as well as terminal renal insufficiency may occur. "
5.	Rare Diseases (Rare Disease) 08/01/2000 - "Primary hyperoxaluria type II (PH2) is a rare disease characterized by the absence of an enzyme with glyoxylate reductase, hydroxypyruvate reductase, and D-glycerate dehydrogenase activities. "

Related Drugs and Biologics

1.	Hydroxypyruvate Reductase
2.	Enzymes
3.	Glycerate dehydrogenase
4.	Alanine-glyoxylate transaminase (alanine-glyoxylate aminotransferase)
5.	Oxidoreductases (Dehydrogenase)
6.	Oxalates
7.	Fructose-Bisphosphate Aldolase (Aldolase)
8.	glyoxylic acid (glyoxylate)
9.	4-hydroxy-2-oxoglutarate aldolase
10.	Hemoglobin Subunits