Abstract | BACKGROUND: OBJECTIVES: METHODS: RESULTS: Sixty evaluable patients were assigned active treatment (monotherapy: 16 male, 14 female; mean age, 7.6 [3.6] years [range, 6-12 years]; combination therapy: 15 male, 15 female; mean age, 7.1 [4.9] years [range, 4-12 years]); the control group comprised 50 healthy children (26 male, 24 female). With both prednisone monotherapy and prednisone + fluvastatin, total and direct bilirubin, and albumin were significantly increased from baseline, and TG, TC, and Upr were significantly decreased (all, P < 0.01). There was no significant difference in treatment effect between the 2 treatment groups. Pretreatment total and direct bilirubin levels were significantly lower in the active-treatment groups than in the control group (n = 50) (all, P < 0.01); after treatment, total and direct bilirubin concentrations were increased to levels reported in the control group. Pre- and posttreatment levels of total bilirubin were positively correlated with albumin but negatively correlated with TC. CONCLUSIONS: CLINICAL TRIAL REGISTRATION: ChiCTR-TQR-12002602.
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Authors | Minghui Song, Anjun Li, Junhua Gong, Dan Yang, Lu Ma, Xinmin Zhou, Yan Yan, Yongxin Xie |
Journal | Clinical therapeutics
(Clin Ther)
Vol. 35
Issue 3
Pg. 286-93
(Mar 2013)
ISSN: 1879-114X [Electronic] United States |
PMID | 23485078
(Publication Type: Journal Article, Randomized Controlled Trial)
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Copyright | Copyright © 2013. Published by EM Inc USA. |
Chemical References |
- Fatty Acids, Monounsaturated
- Indoles
- Fluvastatin
- Cholesterol
- Bilirubin
- Prednisone
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Topics |
- Bilirubin
(blood)
- Child
- Cholesterol
(blood)
- Drug Therapy, Combination
- Fatty Acids, Monounsaturated
(administration & dosage, therapeutic use)
- Female
- Fluvastatin
- Humans
- Indoles
(administration & dosage, therapeutic use)
- Male
- Nephrosis, Lipoid
(drug therapy)
- Prednisone
(administration & dosage, therapeutic use)
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