Podoplanin expression in oral leukoplakia: tumorigenic role.

Abstract

OBJECTIVES:

Recent studies have identified podoplanin, a mucin-type transmembrane glycoprotein, as a biomarker for oral cancer risk in patients with oral leukoplakia (OPL). The aim of this study was to investigate the potential association between podoplanin and the risk of malignant transformation of OPL with epithelial dysplasia.

MATERIALS AND METHODS:

In this retrospective study, podoplanin immunoexpression was analyzed in 58 patients with oral leukoplakia that showed epithelial dysplasia. Lesions with podoplanin expression in the basal and suprabasal layers of oral epithelium at one area or showing suprabasal expression at two or more areas were considered as positive. Association between podoplanin expression and oral cancer development was analyzed.

RESULTS:

Twenty-two of the 58 lesions (38%) were classified as podoplanin-positive, and the remaining 36 (62%) lesions were considered podoplanin-negative. The expression of podoplanin was correlated with the grade of dysplasia (p<0.0005), and with the risk of progression to oral cancer (p<0.0005). In multivariate survival analysis, only premalignant oral lesions displaying positive podoplanin expression showed a significantly increased risk of developing an oral squamous cell carcinoma (hazard ratio=8.738, p=0.007).

CONCLUSION:

Podoplanin could be a valuable biomarker for risk assessment of malignant transformation in patients with OPL along with histological assessment.

• Authors: Juan Carlos de Vicente, Juan Pablo Rodrigo, Tania Rodriguez-Santamarta, Paloma Lequerica-Fernández, Eva Allonca, Juana María García-Pedrero
• Journal: Oral oncology (Oral Oncol) Vol. 49 Issue 6 Pg. 598-603 (Jun 2013) ISSN: 1879-0593 [Electronic] England
• PMID: 23473850 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 Elsevier Ltd. All rights reserved.

Chemical References

• Biomarkers, Tumor
• Membrane Glycoproteins
• PDPN protein, human

Topics

• Aged
• Biomarkers, Tumor (metabolism)
• Carcinogenesis
• Female
• Humans
• Leukoplakia, Oral (metabolism, pathology)
• Male
• Membrane Glycoproteins (metabolism)
• Middle Aged
• Mouth Neoplasms (metabolism, pathology)
• Retrospective Studies