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Mouth Neoplasms (Oral Cancer)

Subscribe to New Research on Mouth Neoplasms

Tumors or cancer of the MOUTH.

Also Known As:

Oral Cancer; Mouth Cancer; Cancer of the Mouth; Neoplasms, Mouth; Neoplasms, Oral; Cancer, Mouth; Cancer, Oral; Cancers, Mouth; Cancers, Oral; Mouth Cancers; Mouth Neoplasm; Neoplasm, Mouth; Neoplasm, Oral; Oral Cancers; Oral Neoplasm; Cancer of Mouth; Oral Neoplasms

Networked: 3074 relevant articles (101 outcomes, 616 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Carcinoma (Carcinomatosis)
3.	Squamous Cell Carcinoma (Epidermoid Carcinoma)
4.	Mouth Neoplasms (Oral Cancer)
5.	Leukoplakia

Experts

1.	Yang, Shun-Fa: 34 articles (12/2015 - 06/2003)
2.	Tsai, Ming-Hsui: 27 articles (07/2014 - 01/2004)
3.	Lin, Chiao-Wen: 25 articles (12/2015 - 09/2010)
4.	Chen, Mu-Kuan: 23 articles (11/2015 - 04/2010)
5.	Yapijakis, Christos: 22 articles (08/2009 - 05/2005)
6.	Vairaktaris, Eleftherios: 22 articles (08/2009 - 05/2005)
7.	Nkenke, Emeka: 21 articles (08/2009 - 01/2007)
8.	Schwint, Amanda E: 19 articles (02/2015 - 03/2003)
9.	Vylliotis, Antonis: 19 articles (08/2009 - 05/2005)
10.	Patsouris, Efstratios: 19 articles (08/2009 - 01/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Mouth Neoplasms:

1.	Fluorouracil (Carac)FDA LinkGeneric 10/27/2015 - "Self-Assembling Monomeric Nucleoside Molecular Nanoparticles Loaded with 5-FU Enhancing Therapeutic Efficacy against Oral Cancer." 08/01/2001 - "In this study, we performed combined therapy of CDGP and fluorouracil (5-FU) for 8 patients with oral cancers, and evaluated the results to elucidate the clinical effect and adverse side effects. " 05/01/2014 - "The BRCA2 gene is a potential molecular target during 5-fluorouracil therapy in human oral cancer cells." 09/01/2012 - "These results indicate that sequential treatment with DOC followed by 5-FU could be a promising therapeutic strategy for oral cancer." 06/01/2005 - "Silencing of the p53R2 gene by RNA interference inhibits growth and enhances 5-fluorouracil sensitivity of oral cancer cells."
2.	Tolonium Chloride FDA Link 01/01/2012 - "A study to evaluate the efficacy of toluidine blue and cytology in detecting oral cancer and dysplastic lesions." 05/01/1989 - "This study used meta-analysis, an analytical technique that uses raw data from previous researchers, to estimate the efficacy of screening for oral cancer with tolonium chloride (TCl). " 02/23/2009 - "Originally developed for detecting abnormal growths on the uterine cervix, in 2001 it received FDA clearance for "identification, evaluation, and monitoring of oral mucosal abnormalities in a patient population at increased risk for oral cancer." The toluidine blue marking system was cleared for inclusion in 2005." 04/01/2014 - "Chemiluminescence and Toluidine Blue as Diagnostic Tools for Detecting Early Stages of Oral Cancer: An invivo Study." 01/01/2013 - "Randomised controlled trials (RCTs) of screening for oral cancer or potentially malignant disorders using visual examination, toluidine blue, fluorescence imaging or brush biopsy. "
3.	1-phenyl-3,3-dimethyltriazene (PDT)IBA 10/01/2014 - "In this study, we determined PDT resistance by autophagy and apoptosis in HP-PDT-treated oral cancer cells. " 07/01/2011 - "Future studies on how NF-κB and JNK activity regulate ALA-PDT response should provide a better strategy for the treatment of oral cancer." 03/01/2015 - "4% (w/w) CH based mucoadhesive gel can be explored as a TBO delivery system in the PDT of oral cancer." 10/01/2014 - "PDT resistance is related to autophagy by PARP-1 regulation in oral cancer cells." 10/01/2014 - "Taken together, HP-PDT induces apoptotic cell death with autophagy in oral cancer cells. "
4.	Biological Markers (Surrogate Marker)IBA 10/01/2011 - "Sensitive and specific biomarkers for oral cancer are likely to be most effective for screening, diagnosis, staging and follow-up for this dreaded malignancy. " 01/01/2015 - "Building a gold standard to construct search filters: a case study with biomarkers for oral cancer." 03/01/2015 - "The current study was undertaken with a view to identify differential biomarkers in chewing-tobacco-associated oral cancer tissues in patients of Indian ethnicity. " 11/01/2013 - "In identifying aberrant DNA methylation at the earliest stages of oral precancer and finding recurring epigenetic disruption of specific genes/pathways across our analyzed cohort, we see evidence that CpG methylation changes may play a role in oral cancer progression and that global DNA methylation analyses may have significant utility in wider studies that seek to derive biomarkers or potentially druggable targets to improve oral cancer outcomes." 01/01/2011 - "This study identifies a tractable number of genomic alterations with few underlying genes that may potentially be utilized as biological markers for prognosis and treatment decisions in oral cancers."
5.	Cisplatin (Platino)FDA LinkGeneric 08/01/2014 - "Its antitumor activity and mechanism in cisplatin-resistant CAR human oral cancer cells were investigated in this study. " 01/01/2000 - "The results of this study suggest that the concomitant use of daily administration of low-dose cisplatin with preoperative radiation brings no statistically significant benefit in improving local control and survival rate in patients with advanced resectable oral cancer." 11/01/2015 - "Clonogenic survival assays and an orthotopic mouse model of HPV(+) oral cancer were used to examine the in vitro and in vivo sensitivity of HPV(+) HNSCC cell lines to AZD-1775 in combination with cisplatin, respectively. " 01/01/2015 - "An oral cancer line stimulated with OPN exhibited a dose-dependent resistance to cisplatin treatment. " 01/01/2015 - "In addition, MTT/colony formation assay was used to estimate the influence of OPN in an oral cancer cell line treated with cisplatin. "
6.	TeaIBA 03/01/2002 - "Therefore, regular consumption of green tea could be beneficial in the prevention of oral cancer." 04/01/1999 - "The overall results provide some direct evidence on the protective effects of tea on oral cancer." 09/01/2013 - "The results of this study indicated that green tea consumption may decrease the risk of oral cancer in men especially for those smoking heavily." 01/27/2010 - "In this study, (-)-epigallocatechin-3-gallate (EGCG), the major constituent of green tea, is found to significantly inhibit the expression of IDO in human oral cancer cell lines. " 11/01/2009 - "Oral cancer prevention advances with a translational trial of green tea."
7.	beta Carotene (Betacarotene)FDA Link 02/01/1995 - "Emerging role of beta-carotene and antioxidant nutrients in prevention of oral cancer." 02/01/1992 - "In this article, the roles of fat, fiber, and beta-carotene are reviewed with respect to the genesis of breast, colon, prostate, lung, and oral cancers. " 03/15/1986 - "Beta-carotene was estimated in exfoliated oral mucosa cells in groups of individuals at various risks for oral cancer. " 03/15/1986 - "Beta-carotene levels in exfoliated mucosa cells of population groups at low and elevated risk for oral cancer." 01/01/1993 - "Previous studies have shown that beta-carotene and alpha-tocopherol can act synergistically to inhibit the growth of experimentally induced oral cancer. "
8.	AntioxidantsIBA 01/01/2014 - "This review is an attempt to understand the interesting correlation between ROS and RNS mediated cell damage and enzymatic and non-enzymatic defence mechanisms involved in oral cancer development and its progression and the use of antioxidants in oral cancer prevention and treatment. " 12/01/2005 - "The altered lipid peroxidation in plasma and erythrocytes of oral cancer patients may be related to their compensatory changes in the antioxidants defense system." 12/01/2005 - "Elevated lipid peroxidation and decline in non-enzymatic and enzymatic antioxidants status were noticed in oral cancer patients as compared to healthy subjects. " 11/01/2005 - "In contrast, decrease in antioxidants (GSH, GPx, GR and AA p < 0.001, SOD p < 0.05 respectively) was observed in the blood of oral cancer patients, as compared with healthy subjects. " 01/01/2004 - "Temporal patterns of lipid peroxidation product formation and antioxidants activity in oral cancer patients."
9.	polyphenolsIBA 08/01/2013 - "The protective effects of grape polyphenols have been reported on oral health, though unreasonable alcohol consumption represents a risk factor for developing oral cancer. " 06/01/2013 - "In this review, we discuss current progress of dietary polyphenols against oral cancers in vitro, in vivo, and at population levels." 06/01/2013 - "Protection of dietary polyphenols against oral cancer." 01/01/2012 - "However, a fascinating starting point has been provided by pre-clinical studies that have shown interesting activities of polyphenols against the most common oral diseases (caries, periodontitis and candidiasis), as well as in oral cancer prevention." 06/01/2013 - "In particular, dietary polyphenols decrease incidence of carcinomas and exert protection against oral cancer by induction of cell death and inhibition of tumor growth, invasion, and metastasis. "
10.	Liposomes (Liposome)IBA 11/11/2014 - "The application of boron neutron capture therapy (BNCT) mediated by liposomes containing (10)B-enriched polyhedral borane and carborane derivatives for the treatment of head and neck cancer in the hamster cheek pouch oral cancer model is presented. " 09/01/2002 - "These results demonstrate the potential utility of liposome-derived angiostatin for adjuvant therapy of oral cancer in humans." 04/23/2002 - "f-PEG-PE has been shown to facilitate FR-mediated endocytosis of liposomes into KB human oral cancer cells, which express amplified FR. " 11/11/2014 - "Therapeutic efficacy of boron neutron capture therapy mediated by boron-rich liposomes for oral cancer in the hamster cheek pouch model." 05/01/2012 - "Boron delivery with liposomes for boron neutron capture therapy (BNCT): biodistribution studies in an experimental model of oral cancer demonstrating therapeutic potential."

Therapies and Procedures

1.	Chemoprevention 01/01/2011 - "The purpose of this review was to identify prominent oral cancer chemoprevention clinical trials, assess their overall therapeutic efficacy, and delineate effects of local versus systemic drug administration. " 01/01/2011 - "Over the last several decades, numerous oral cancer chemoprevention clinical trials have assessed the therapeutic efficacy of diverse chemopreventive agents. " 01/01/2011 - "Optimizing therapeutic efficacy of chemopreventive agents: A critical review of delivery strategies in oral cancer chemoprevention clinical trials." 11/08/2004 - "Our findings indicate that this new combined treatment is safe and effective for oral cancer chemoprevention, and warrants further study." 01/01/2013 - "Together, the findings of this study, particularly the improved understanding of the selective killing mechanisms of 4βHWE, can be used to improve efficiency in killing oral cancer cells during chemoprevention and therapy."
2.	Drug Therapy (Chemotherapy) 02/01/2002 - "Long-term complete remission of oral cancer after anti-neoplastic chemotherapy as single treatment modality: role of local chemotherapy." 05/01/1997 - "Recent advances in chemotherapy have markedly improved the treatment results for oral cancer. " 09/01/2015 - "A total of 37 patients who had oral cancer and had received 68 courses (total) of chemotherapy were found to be eligible for this study. " 01/01/2015 - "Compared with previous studies, oral cancer patients near death in this nationwide study had a far higher utilization rate (>50%) of chemotherapy, emergency room services, and intensive care unit services. " 11/01/2012 - "Twenty-five patients with oral cancer who were treated by intra-arterial chemotherapy were included in this study. "
3.	Boron Neutron Capture Therapy 04/01/2015 - "We previously reported the therapeutic efficacy of Sequential Boron Neutron Capture Therapy (Seq-BNCT), i.e., BPA (boronophenylalanine) - BNCT followed by GB-10 (decahydrodecaborate) - BNCT 1 or 2 days later, in the hamster cheek pouch oral cancer model. " 03/01/2011 - "We previously demonstrated the therapeutic efficacy of different boron neutron capture therapy (BNCT) protocols in an experimental model of oral cancer. " 02/01/2015 - "The hamster cheek pouch model of oral cancer was also proposed and validated by our group for boron neutron capture therapy studies for the treatment of oral cancer. " 12/15/2001 - "Herein we propose and validate the hamster cheek pouch model of oral cancer for boron neutron capture therapy (BNCT) studies. " 01/01/2015 - "We previously demonstrated the therapeutic success of sequential boron neutron capture therapy (Seq-BNCT) in the hamster cheek pouch oral cancer model. "
4.	Radiotherapy 01/01/2014 - "However, development of radioresistance is a major hurdle in the efficacy of radiotherapy in oral cancer patients. " 02/01/1986 - "[Efficacy of radiotherapy of cancer of the mouth mucosa]." 05/01/2015 - "To understand radiotherapy-induced dental lesions characterized by enamel loss or delamination near the dentine-enamel junction (DEJ), this study evaluated enamel and dentine nano-mechanical properties and chemical composition before and after simulated oral cancer radiotherapy. " 06/01/2014 - "This study highlights the variability in the approach of clinicians in dental and oral rehabilitation of patients undergoing radiotherapy treatment for oral cancer patients." 10/01/2013 - "Our study suggests that Bcl-xL expression along with clinical parameters may be useful for identifying patients with oral cancer likely to draw maximum benefit from curative radiotherapy."
5.	Heterologous Transplantation (Xenotransplantation) 07/14/2012 - "Therefore, the present study investigated whether SAC consumption would help prevent tumour growth and progression, including the EMT, in a mouse xenograft model of oral cancer. " 02/01/2005 - "In this study, we attempted to use a non-viral gene transfer system, in vivo electroporation, in oral cancer cell B88 xenografts. " 07/14/2012 - "These results show that SAC has potential as an agent against tumour growth and the progression of oral cancer in a mouse xenograft model." 11/01/2007 - "Radiation was given (2 Gy/day; 5 days/week) for a total of 60 Gy. In nude mouse models, human oral cancer cell lines were used as subcutaneous xenografts in nude mice. " 02/01/2005 - "Next, to estimate the reduction of oral cancer xenografts by this method, we measured the size of B88 xenografts in nude mice after electroporation with the wild- or mutant-type p27Kip1 gene. "