Abstract |
This study aims to determine prevalence and incidence of anemia in the general population in Germany and evaluate a potential role of serum-free light chains (FLC) as biomarker in anemia. The population-based Heinz Nixdorf Recall Study comprises 4,814 men and women aged 45-75 years. Hemoglobin <13 g/dl in men and <12 g/dl in women defined anemia. Laboratory data was used to classify cases into renal, iron deficiency (IDA), vitamin B12/ folic acid deficiency, anemia of chronic disease (ACD), and unexplained anemia (UA). Follow-up data was available from annual questionnaires, death certificates, and 5-year follow-up visit (5-year FU). Anemia cases (152) were identified (prevalence 3.2 %, 95 % CI 2.7-3.7). In participants aged 65 or older, prevalence was 4.3 % (95 % CI 2.9-6.0) in both men and women. Main anemia subtypes were: IDA 19 %, ACD 25 %, and UA 44 %. Incidence increased with age and was 12.8/1,000 person-years and 10.9/1,000 person-years in men and women aged 65 or older, respectively. UA was characterized by elevated FLC. Participants with elevated FLC and high-sensitivity C-reactive protein ( hsCRP) had an increased risk of anemia at 5-year FU. FLC-alone or in combination with hsCRP-may serve as biomarker indicating an increased risk of developing anemia.
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Authors | Lewin Eisele, Jan Dürig, Martina Broecker-Preuss, Ulrich Dührsen, Beate Bokhof, Raimund Erbel, Susanne Moebus, Karl-Heinz Jöckel, Heinz Nixdorf Recall Study Investigative Group |
Journal | Annals of hematology
(Ann Hematol)
Vol. 92
Issue 6
Pg. 731-7
(Jun 2013)
ISSN: 1432-0584 [Electronic] Germany |
PMID | 23430088
(Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Hemoglobins
- Immunoglobulin Light Chains
- C-Reactive Protein
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Topics |
- Age Distribution
- Aged
- Anemia
(blood, epidemiology)
- Anemia, Iron-Deficiency
(epidemiology)
- Anemia, Macrocytic
(epidemiology, etiology)
- Biomarkers
- C-Reactive Protein
(analysis)
- Chronic Disease
- Female
- Folic Acid Deficiency
(blood, epidemiology)
- Follow-Up Studies
- Germany
(epidemiology)
- Hemoglobins
(analysis)
- Humans
- Immunoglobulin Light Chains
(blood)
- Incidence
- Male
- Middle Aged
- Prevalence
- Risk
- Sex Distribution
- Vitamin B 12 Deficiency
(blood, epidemiology)
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