Towards magnetic-enhanced cellular uptake, MRI and chemotherapeutics delivery by magnetic mesoporous silica nanoparticles.

Abstract

A type of nanoparticle with three functional modalities was prepared with the aim of providing a multifunctional drug delivery system. The nanoparticle was 50 nm in size, with 2.7 nm mesopores and a magnetic nanocrystal core, which was further doped with FITC to enable the tracking of cellular uptake. We demonstrated that the internalization of the nanoparticles in tumor cells could be enhanced by applying an external magnetic field and furthermore, this kind of nanoparticle could be used in magnetic targeted drug delivery. With high transverse relaxivity, the magnetic nanoparticles shortened proton relaxation time and induced high magnetic resonance imaging contrast in tumor cells. Studies on anticancer drug loading and delivery capacity of anticancer drugs also showed that this type of nanoparticles could load water-soluble doxorubicin, and produce a prominent inhibitive effect against tumor cells. Taken together, the presented nanoparticles could become a promising agent in cancer theranostics.

• Authors: Qian Liu, Jixi Zhang, Weiliang Xia, Hongchen Gu
• Journal: Journal of nanoscience and nanotechnology (J Nanosci Nanotechnol) Vol. 12 Issue 10 Pg. 7709-15 (Oct 2012) ISSN: 1533-4880 [Print] United States
• PMID: 23421131 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Drug Carriers
• Silicon Dioxide

Topics

• Antineoplastic Agents (administration & dosage)
• Cell Line, Tumor
• Drug Carriers
• Humans
• Magnetic Resonance Imaging (methods)
• Magnetics
• Microscopy, Electron, Transmission
• Nanoparticles
• Silicon Dioxide