Chemopreventive effects of 4-methylthio-3-butenyl Isothiocyanate (Raphasatin) but not curcumin against pancreatic carcinogenesis in hamsters.

Abstract

The modifying effects of 4-methylthio-3-butenyl isothiocyanate (MTBITC) and curcumin were investigated in N-nitrosobis(2-oxopropyl)amine (BOP)-initiated hamsters. Male 6-week-old Syrian hamsters were subcutaneously injected with 10 mg/kg body weight (b.w.) of BOP four times a week, and fed a diet supplemented with 80 mg/kg diet of MTBITC, equivalent to 4.6 mg/kg b.w./day for the initiation stage or 3.8 mg/kg b.w./day for the postinitiation stage administration, respectively, or 2000 mg/kg diet of curcumin, equivalent to 118.8 mg/kg b.w./day for the initiation stage or 100.8 mg/kg b.w./day for the postinitiation stage administration, respectively. The incidence of combined pancreatic lesions, including atypical hyperplasias and adenocarcinomas, was significantly decreased to 55% (P < 0.05) by the 80 mg/kg diet MTBITC given during the initiation stage as compared to the BOP alone group (85%) but not by the curcumin administration at 16 weeks after the BOP-treatment. In the second study, the multiplicity of combined pancreatic lesions was also significantly decreased to 0.50 ± 0.51 (P < 0.05) by 700 mg/kg diet MTBITC given in the initiation stage (equivalent to 59.0 mg/kg b.w./day) as compared to the BOP alone group (1.10 ± 1.02). Our results indicate that the naturally occurring isothiocyanate MTBITC may exert preventive effects against BOP-initiation of hamster pancreatic carcinogenesis.

• Authors: Toshiya Okamura, Takashi Umemura, Tomoki Inoue, Masako Tasaki, Yuji Ishii, Yasushi Nakamura, Eun Young Park, Kenji Sato, Tomoaki Matsuo, Shigehisa Okamoto, Akiyoshi Nishikawa, Kumiko Ogawa
• Journal: Journal of agricultural and food chemistry (J Agric Food Chem) Vol. 61 Issue 9 Pg. 2103-8 (Mar 06 2013) ISSN: 1520-5118 [Electronic] United States
• PMID: 23387327 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 4-(methylthio)-3-butenyl isothiocyanate
• Anticarcinogenic Agents
• Carcinogens
• Isothiocyanates
• Nitrosamines
• nitrosobis(2-oxopropyl)amine
• Curcumin

Topics

• Adenocarcinoma (chemically induced, pathology, prevention & control)
• Animals
• Anticarcinogenic Agents
• Carcinogens (administration & dosage)
• Cricetinae
• Curcumin (administration & dosage)
• Diet
• Hyperplasia
• Isothiocyanates (administration & dosage)
• Male
• Mesocricetus
• Nitrosamines (administration & dosage)
• Pancreas (pathology)
• Pancreatic Neoplasms (chemically induced, pathology, prevention & control)