Abstract | OBJECTIVES: MATERIALS AND METHODS: Forty subjects (20 males and 20 females) were selected and divided into four groups (10 subjects in each group), based on clinical parameters: group NOH (non-obese healthy), group OH (obese healthy), Group NOCP (non-obese with chronic periodontitis) and group OCP (obese with chronic periodontitis). The levels of serum and GCF MCP-4 were determined by ELISA and hsCRP levels were determined by immunoturbidimetry method. RESULTS: The mean GCF and serum concentration of MCP-4 was highest for group OCP followed by group NOCP, group OH (in GCF); group OH, group NOCP(in serum) and least in group NOH. The mean hsCRP concentration was highest for group OCP followed by group OH, group NOCP and group NOH. A significant positive correlation was found between serum and GCF MCP-4 and hsCRP levels. CONCLUSION: GCF MCP-4 concentrations increased in periodontal disease compared to health and correlated positively with the severity of disease indicating it as a novel marker of periodontal disease. The serum concentration of MCP-4 was found to be more in obese group as compared to nonobese group indicating it as a marker of obesity. Furthermore, based on the positive correlation of MCP-4 and hsCRP found in this study, it can be proposed that MCP-4 and hsCRP may be the markers linking chronic inflammation in obesity and periodontal disease.
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Authors | A R Pradeep, Minal Kumari, Nitish Kalra, N Priyanka |
Journal | Cytokine
(Cytokine)
Vol. 61
Issue 3
Pg. 772-7
(Mar 2013)
ISSN: 1096-0023 [Electronic] England |
PMID | 23375121
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2013 Elsevier Ltd. All rights reserved. |
Chemical References |
- Biomarkers
- CCL13 protein, human
- Monocyte Chemoattractant Proteins
- C-Reactive Protein
|
Topics |
- Adult
- Analysis of Variance
- Biomarkers
(blood)
- Body Mass Index
- C-Reactive Protein
(metabolism)
- Chronic Periodontitis
(blood, complications)
- Female
- Gingival Crevicular Fluid
(metabolism)
- Humans
- Inflammation
(blood, complications)
- Male
- Middle Aged
- Monocyte Chemoattractant Proteins
(blood)
- Obesity
(blood, complications)
- Periodontal Index
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