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Successful treatment of digital tip necrosis in rheumatoid vasculitis with anti-CD20 antibody rituximab.

Abstract
We report a successful treatment with rituximab in the case of rheumatoid vasculitis causing digital tips necrosis in exacerbated rheumatoid arthritis. The vasculitis lesions did not respond completely to intravenous methylprednisolone and cyclophosphamide but responded on rituximab treatment. Deep necrosis of a digital tip resolved entirely after completing a course of rituximab.
AuthorsMariusz Korkosz, Jarosław Królczyk, Dorota Telesińska-Jasiówka, Tomasz Grodzicki
JournalJournal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases (J Clin Rheumatol) Vol. 19 Issue 1 Pg. 43-5 (Jan 2013) ISSN: 1536-7355 [Electronic] United States
PMID23319024 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antibodies, Monoclonal, Murine-Derived
  • Antirheumatic Agents
  • Rituximab
  • Cyclophosphamide
  • Methylprednisolone
Topics
  • Antibodies, Monoclonal, Murine-Derived (therapeutic use)
  • Antirheumatic Agents (therapeutic use)
  • Cyclophosphamide (therapeutic use)
  • Female
  • Fingers (pathology)
  • Humans
  • Methylprednisolone (therapeutic use)
  • Middle Aged
  • Necrosis
  • Rheumatoid Vasculitis (drug therapy, pathology)
  • Rituximab
  • Treatment Failure
  • Treatment Outcome

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