Rheumatoid Vasculitis

Necrotizing VASCULITIS of small and medium size vessels, developing as a complication in RHEUMATOID ARTHRITIS patients. It is characterized by peripheral vascular lesions, cutaneous ULCERS, peripheral GANGRENE, and MONONEURITIS MULTIPLEX.

Also Known As:

Networked: 146 relevant articles (11 outcomes, 11 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Rheumatoid Arthritis
2.	Amyloidosis
3.	Interstitial Nephritis (Tubulointerstitial Nephritis)
4.	Vasculitis (Vasculitides)
5.	Necrosis

Experts

1.	Matteson, Eric L: 4 articles (01/2015 - 05/2004)
2.	Turesson, Carl: 3 articles (01/2009 - 05/2004)
3.	Nishimura, Wester Eidi: 2 articles (06/2015 - 05/2012)
4.	Bertolo, Manoel Barros: 2 articles (06/2015 - 05/2012)
5.	Takaichi, Kenmei: 2 articles (01/2015 - 01/2011)
6.	Sumida, Keiichi: 2 articles (01/2015 - 01/2011)
7.	Ubara, Yoshifumi: 2 articles (01/2015 - 01/2011)
8.	Carlson, J Andrew: 2 articles (01/2008 - 09/2006)
9.	Breedveld, Ferdinand C: 2 articles (08/2005 - 02/2004)
10.	Costallat, Lilian Teresa Lavras: 1 article (06/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Rheumatoid Vasculitis:

1.	Immunoglobulin G (IgG)IBA 05/01/1991 - "When patient groups were formed according to the results of longitudinal studies, however, degradation of aggregated IgG mediated by Fc and (Fc + C) receptors was significantly decreased in patients with rheumatoid vasculitis and in patients with active RA in comparison with patients with inactive RA and healthy controls. " 05/01/1991 - "To investigate whether a relation exists between the receptor mediated degradation of aggregated IgG by adherent monocytes and disease activity a longitudinal study was performed in 79 patients with RA and rheumatoid vasculitis over a period of 16 months. " 11/01/1991 - "In this study we made use of an ELISA and immunoblot technique (IBT) to further characterize AEA of the IgG class in serum of patients with rheumatoid vasculitis (RV) and to investigate the relationship between the presence of IgG-AEA and vasculitis. " 08/01/1987 - "Adherent monocytes from 33 patients with active rheumatoid arthritis (RA) and rheumatoid vasculitis, 32 patients with inactive RA alone, and 20 healthy controls were incubated with 125I-aggregated IgG (125I-AIgG) of restricted size with or without fresh serum. " 06/27/1981 - "Further studies of complement- and Fc-mediated monocyte phagocytosis in which the rate constants (Kc and KFc respectively) were determined using complement-coated Saccharomyces cerevisiae and Candida albicans opsonised with IgG in monocytes from nine patients with rheumatoid vasculitis and 12 controls showed a significant reduction in Kc (p less than 0.01) but normal KFc. "
2.	Cyclophosphamide (Cytoxan)FDA LinkGeneric 01/01/2015 - "The incidence of rheumatoid vasculitis has declined significantly in the past several decades, but morbidity and mortality continue to remain high, despite aggressive treatment with cyclophosphamide or biologic agents. " 10/14/1988 - "Cyclophosphamide is generally considered too toxic for use in patients with rheumatoid arthritis, although it may be helpful in patients with systemic rheumatoid vasculitis or patients who have failed all other therapies.(ABSTRACT TRUNCATED AT 400 WORDS)" 01/01/1990 - "Fifteen patients suffering from severe systemic diseases were treated with monthly pulses administration of cyclophosphamide (0.7 g/m2 of body surface): 8 acute systemic lupus erythematosus, 2 Wegener's granulomatous, 1 polyarteritis nodosa, 1 rheumatoid vasculitis, 1 progressive systemic sclerosis, 1 relapsing uveitis and 1 dermatopolymyositis. " 09/01/1980 - "Thus, circulating immune complexes appear to be involved in the immunopathogenesis of rheumatoid vasculitis, which can be successfully treated with cyclophosphamide." 09/01/1980 - "A study of five patients with severe rheumatoid vasculitis treated with cyclophosphamide was undertaken to determine whether immune complexes were present in serum and if their levels correlated with disease activity and response to treatment. "
3.	Antigen-Antibody Complex (Immune Complex)IBA 12/01/2002 - "Rheumatoid vasculitis has been understood to be the result of severe disease extending beyond the joint, possibly caused by immune complex deposition. " 01/01/2001 - "Immune complexes (IC) are frequently detected in patients with rheumatoid vasculitis (RV). " 05/01/1994 - "Rheumatoid vasculitis has been understood to be the result of severe disease extending beyond the joint, possibly caused by immune complex deposition. " 08/01/1988 - "Immune complexes in sera from patients with rheumatoid vasculitis induce polymorphonuclear cell-mediated injury to endothelial cells." 01/01/1984 - "In systemic immune complex (IC) diseases such as SLE and rheumatoid vasculitis, IC accumulate in a number of tissues, either after deposition from the circulation or from in situ formation. "
4.	Complement System Proteins (Complement)IBA 01/01/1990 - "Complement-mediated inhibition of immune precipitation in rheumatoid vasculitis." 07/18/1981 - "Complement-mediated phagocytosis in rheumatoid vasculitis." 04/01/2013 - "Significant positive correlations of CD4+ T lymphocytopenia with other risk factors (parotid swelling, vasculitis, rheumatoid factors, low complement, cryoglobulinemia) were detected. " 01/01/1990 - "Complement-mediated inhibition of immune precipitation (CMIP) was measured in patients with rheumatoid arthritis (RA), rheumatoid vasculitis (RA VASC), patients with skin vasculitis not associated with a systemic connective tissue disease and normal healthy controls. " 06/27/1981 - "Further studies of complement- and Fc-mediated monocyte phagocytosis in which the rate constants (Kc and KFc respectively) were determined using complement-coated Saccharomyces cerevisiae and Candida albicans opsonised with IgG in monocytes from nine patients with rheumatoid vasculitis and 12 controls showed a significant reduction in Kc (p less than 0.01) but normal KFc. "
5.	Azathioprine (Imuran)FDA LinkGeneric 11/01/1973 - "Proceedings: Controlled trial of azathioprine in rheumatoid vasculitis." 11/01/1991 - "We conclude that the combination of prednisone and azathioprine is effective in the treatment of severe systemic rheumatoid vasculitis; rheumatoid vasculitis with only cutaneous manifestations has a relatively good prognosis, and there is probably no indication for therapy specifically directed at the vasculitic process." 11/01/1991 - "The therapeutic effect of prednisone combined with azathioprine was studied in 28 patients with rheumatoid vasculitis. "
6.	Immunoglobulin M (IgM)IBA 08/01/1980 - "Patients with active rheumatoid arthritis had significantly more 7S IgM than those with inactive disease, but there was no significant difference between those patients with and without rheumatoid vasculitis. " 10/01/1987 - "Laboratory data provided little prognostic information with regard to rheumatoid vasculitis, with the exception that IgM and IgG rheumatoid factors were significantly higher among patients with fatal course of disease than in those who achieved remission." 06/01/1981 - "High levels were seen in RA, particularly in rheumatoid vasculitis and Felty's syndrome, and significant correlations occurred between LMW IgM and the rheumatoid factor (RF) level and other indices that reflected active or severe disease. " 03/01/1986 - "Serum IgA and IgM RF from patients with rheumatoid arthritis or the sicca syndrome showed considerable charge heterogeneity whereas IgM RF from mixed cryoglobulinaemia or rheumatoid vasculitis patients showed monoclonal and oligoclonal banding patterns respectively. " 10/01/1985 - "Rheumatoid vasculitis is an example of the latter type of arteritis associated with high-titer 19S IgM rheumatoid factor typically occurring in patients with long-standing erosive rheumatoid arthritis. "
7.	Penicillamine (Cuprimine)FDA Link 05/01/1990 - "Most clinical experience in managing more symptomatic rheumatoid vasculitis has focused on glucocorticosteroids, D-penicillamine, and cytotoxic immunosuppressive drugs.(ABSTRACT TRUNCATED AT 400 WORDS)" 05/01/1979 - "D-penicillamine in the treatment of rheumatoid vasculitis." 01/01/1985 - "A patient with advanced rheumatoid arthritis and severe clinical manifestations of rheumatoid vasculitis died of acute renal failure after 30 months of treatment with high-dosage D-penicillamine. " 12/30/1983 - "Conditions often associated with rheumatoid arthritis and also thought to have an immunologic basis, such as Sjögren's syndrome, Felty's syndrome, and rheumatoid vasculitis, and reactions to medications, such as gold and penicillamine, reveal an interesting spectrum of immunogenetic relationships. " 03/01/1994 - "In particular, we describe renal syndromes associated with non-steroidal antiinflammatory drugs, remission-inducing agents (gold and penicillamine) and cytotoxic drugs, secondary amyloidosis, systemic rheumatoid vasculitis, glomerular and tubulo-interstitial nephritis not related to drug therapy."
8.	rituximab (Mabthera)FDA Link 03/12/2014 - "Regarding the treatment of rheumatoid vasculitis, rituximab looks promising. " 03/01/2012 - "We assessed the efficacy and safety of rituximab in a real-life clinical setting among patients with systemic rheumatoid vasculitis (SRV). " 11/01/2006 - "Successful treatment of rheumatoid vasculitis-associated foot drop with rituximab." 01/01/2010 - "To test the efficacy of treatment with rituximab in refractory rheumatoid vasculitis in patients with rheumatoid arthritis (RA). " 01/01/2013 - "Successful treatment of digital tip necrosis in rheumatoid vasculitis with anti-CD20 antibody rituximab."
9.	Prednisone (Sone)FDA LinkGeneric 05/01/1987 - "Cutaneous Kaposi's sarcoma developed eight months after initiation of prednisone treatment in a 58-year-old man with systemic rheumatoid disease (rheumatoid arthritis, Felty's syndrome, rheumatoid vasculitis, and myositis). " 11/01/1991 - "We conclude that the combination of prednisone and azathioprine is effective in the treatment of severe systemic rheumatoid vasculitis; rheumatoid vasculitis with only cutaneous manifestations has a relatively good prognosis, and there is probably no indication for therapy specifically directed at the vasculitic process." 11/01/1991 - "The therapeutic effect of prednisone combined with azathioprine was studied in 28 patients with rheumatoid vasculitis. "
10.	GoldIBA 12/30/1983 - "Conditions often associated with rheumatoid arthritis and also thought to have an immunologic basis, such as Sjögren's syndrome, Felty's syndrome, and rheumatoid vasculitis, and reactions to medications, such as gold and penicillamine, reveal an interesting spectrum of immunogenetic relationships. " 03/01/1994 - "In particular, we describe renal syndromes associated with non-steroidal antiinflammatory drugs, remission-inducing agents (gold and penicillamine) and cytotoxic drugs, secondary amyloidosis, systemic rheumatoid vasculitis, glomerular and tubulo-interstitial nephritis not related to drug therapy."

Therapies and Procedures

1.	Plasmapheresis 04/01/1984 - "Our preliminary results suggest that plasmapheresis, used as an acute treatment modality, and combined with prolonged therapy with immunosuppressive drugs, may reduce the morbidity associated with certain manifestations of rheumatoid vasculitis." 04/01/1984 - "The combined effects of plasmapheresis and immunosuppressive therapy in the treatment of rheumatoid vasculitis was evaluated in 8 patients. " 04/01/1984 - "Efficacy of combined therapy with plasmapheresis and immunosuppressants in rheumatoid vasculitis." 12/01/1983 - "Other clinical manifestations considered as reflecting rheumatoid vasculitis (gangrene, mononeuritis multiplex, ulcers) were thought to worsen prognosis and would have been managed more often with corticosteroids, D-penicillamine, cytotoxic agents or plasmapheresis. "
2.	Drug Therapy (Chemotherapy) 01/01/1993 - "This case suggests an association between antecedent RA and splenic lymphoma, the influence of splenectomy and chemotherapy on occurrence of rheumatoid vasculitis, and a causal relationship between CPM and bladder cancer." 03/01/1994 - "In particular, we describe renal syndromes associated with non-steroidal antiinflammatory drugs, remission-inducing agents (gold and penicillamine) and cytotoxic drugs, secondary amyloidosis, systemic rheumatoid vasculitis, glomerular and tubulo-interstitial nephritis not related to drug therapy."
3.	Lasers (Laser) 12/01/2007 - "In search of a noninvasive diagnostic test for rheumatoid vasculitis (RV), this study addressed the questions whether changes in capillary blood cell velocity (CBV) detected by laser Doppler anemometry in patients with rheumatoid arthritis (RA) were correlated with the levels of soluble adhesion molecules and whether cutaneous flow abnormalities may reflect extraarticular manifestations in RA. "
4.	Plasma Exchange 01/01/1985 - "Four of 4 (100%) rheumatoid vasculitis patients treated by cryofiltration and 4 of 7 (57.1%) patients treated with plasma exchange showed clinical improvement. " 01/01/1983 - "Bullous and pustular rheumatoid vasculitis: treatment by plasma exchange." 01/01/1982 - "Plasma exchange in two patients with rheumatoid vasculitis." 11/01/1981 - "Plasma exchange in rheumatoid vasculitis." 05/01/1981 - "Plasma exchange (PE) was used to treat 9 patients with rheumatoid vasculitis. "
5.	Splenectomy 04/01/2004 - "Rates of hospitalization for rheumatoid vasculitis and splenectomy in Felty's syndrome decreased progressively over time. " 04/01/2004 - "Rates of hospitalization for rheumatoid vasculitis and splenectomy in Felty's syndrome have decreased over the past 19 years, and there has been a recent decrease in the rates of primary total knee arthroplasty in patients with RA. " 04/01/2004 - "Data on all patients with RA who were hospitalized with rheumatoid vasculitis or to undergo splenectomy for Felty's syndrome, cervical spine fusion for myelopathy, or total knee arthroplasty at hospitals in California were abstracted from a state hospitalization database. " 01/01/1993 - "This case suggests an association between antecedent RA and splenic lymphoma, the influence of splenectomy and chemotherapy on occurrence of rheumatoid vasculitis, and a causal relationship between CPM and bladder cancer."