Decreased iron levels in the temporal cortex in postmortem human brains with Parkinson disease.

Abstract

OBJECTIVE:

The present study aimed to evaluate alterations in the levels of iron, divalent metal transporter 1 (DMT1) with the iron-responsive element (IRE), transferrin receptor 1 (TfR1), ferroportin 1 (FPN1), and iron regulatory protein 1 (IRP1) in the temporal cortex of human brains with Parkinson disease (PD).

METHODS:

Iron content was measured using an ICP-MS 7500CE detector. IRP1, DMT1+IRE, TfR1, and FPN1 expressions were determined by Western blotting.

RESULTS:

Iron content was significantly lower in the temporal cortex of patients with PD when compared with age-matched healthy controls. Unexpectedly, the levels of DMT1+IRE, TfR1, FPN1, and IRP1 were decreased in the temporal cortex in PD brains. No changes were observed in the temporal cortex of postmortem Alzheimer disease brains.

CONCLUSIONS:

Iron deprivation and iron-related protein dysregulation suggest that a different iron regulatory mechanism may exist, and that iron redistribution may occur between the temporal cortex and the substantia nigra of patients with PD.

• Authors: Xiaojun Yu, Tingting Du, Ning Song, Qing He, Yong Shen, Hong Jiang, Junxia Xie
• Journal: Neurology (Neurology) Vol. 80 Issue 5 Pg. 492-5 (Jan 29 2013) ISSN: 1526-632X [Electronic] United States
• PMID: 23303856 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Antigens, CD
• CD71 antigen
• Cation Transport Proteins
• Iron-Regulatory Proteins
• Receptors, Transferrin
• metal transporting protein 1
• solute carrier family 11- (proton-coupled divalent metal ion transporters), member 2
• Iron
• Iron Regulatory Protein 1

Topics

• Aged
• Aged, 80 and over
• Alzheimer Disease (metabolism, pathology)
• Antigens, CD (metabolism)
• Case-Control Studies
• Cation Transport Proteins (metabolism)
• Female
• Gene Expression Regulation
• Humans
• Iron (metabolism)
• Iron Regulatory Protein 1 (metabolism)
• Iron-Regulatory Proteins (metabolism)
• Male
• Parkinson Disease (pathology)
• Postmortem Changes
• Receptors, Transferrin (metabolism)
• Spectrophotometry, Atomic
• Temporal Lobe (metabolism)