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Iron Regulatory Protein 1

A multifunctional iron-sulfur protein that is both an iron regulatory protein and cytoplasmic form of aconitate hydratase. It binds to iron regulatory elements found on mRNAs involved in iron metabolism and regulates their translation. Its RNA binding ability and its aconitate hydrolase activity are dependent upon availability of IRON.
Also Known As:
ACO1 Protein; Aconitase 1, Soluble; Ferritin Repressor Protein; IRE-BP1; IRP-1 Protein; IRP1 Protein; IRE BP1; IRP 1 Protein; Repressor Protein, Ferritin; Soluble Aconitase 1
Networked: 41 relevant articles (1 outcomes, 3 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Ghosh, Manik C: 3 articles (01/2021 - 05/2010)
2. Rouault, Tracey A: 3 articles (01/2021 - 05/2010)
3. Zhu, Li: 3 articles (12/2018 - 09/2015)
4. Barati, Michelle T: 3 articles (02/2017 - 10/2008)
5. Villafuerte, Betty C: 3 articles (02/2017 - 10/2008)
6. Aguirre, Pabla: 3 articles (01/2017 - 08/2012)
7. Núñez, Marco T: 3 articles (01/2017 - 08/2012)
8. Noguchi, Audrey: 2 articles (01/2021 - 02/2013)
9. Springer, Danielle A: 2 articles (01/2021 - 02/2013)
10. Zhang, De-Liang: 2 articles (01/2021 - 02/2013)

Related Diseases

1. Parkinson Disease (Parkinson's Disease)
2. Insulin Resistance
3. Breast Neoplasms (Breast Cancer)
4. Hypoxia (Hypoxemia)
5. Neoplasms (Cancer)
04/01/2007 - "Overexpression of iron regulatory protein 1 suppresses growth of tumor xenografts."
01/01/2018 - "Tumor tissue from the patient was further tested for mutations in genes related to upregulation of the hypoxia signaling pathway including iron regulatory protein 1 (IRP1), which is a known regulator of HIF-2α mRNA translation. "
01/01/2022 - "ENO1 suppresses cancer cell ferroptosis by degrading the mRNA of iron regulatory protein 1."
04/16/2015 - "SIRT3 regulates cellular iron metabolism and cancer growth by repressing iron regulatory protein 1."
01/01/2022 - ": acetyl-CoA: acetyl-coenzyme A; ACO1: aconitase 1; ADCYs: adenylate cyclases; AMPK: AMP-activated protein kinase; ATM: ATM serine/threonine kinase; BCL2L1: BCL2 like 1; BCL2L13: BCL2 like 13; BNIP3: BCL2 interacting protein 3; BNIP3L: BCL2 interacting protein 3 like; Ca2+: calcium ion; CALCOCO2: calcium binding and coiled-coil domain 2; CANX: calnexin; CO: carbon monoxide; CYCS: cytochrome c, somatic; DFP: deferiprone; DNM1L: dynamin 1 like; ER: endoplasmic reticulum; FKBP8: FKBP prolyl isomerase 8; FOXO3: forkhead box O3; FTMT: ferritin mitochondrial; FUNDC1: FUN14 domain containing 1; GABA: γ-aminobutyric acid; GSH: glutathione; HIF1A: hypoxia inducible factor 1 subunit alpha; IMMT: inner membrane mitochondrial protein; IRP1: iron regulatory protein 1; ISC: iron-sulfur cluster; ITPR2: inositol 1,4,5-trisphosphate type 2 receptor; KMO: kynurenine 3-monooxygenase; LIR: LC3 interacting region; MAM: mitochondria-associated membrane; MAP1LC3: microtubule associated protein 1 light chain 3; MFNs: mitofusins; mitophagy: mitochondrial autophagy; mPTP: mitochondrial permeability transition pore; MTOR: mechanistic target of rapamycin kinase; NAD+: nicotinamide adenine dinucleotide; NAM: nicotinamide; NMN: nicotinamide mononucleotide; NO: nitric oxide; NPA: Niemann-Pick type A; NR: nicotinamide riboside; NR4A1: nuclear receptor subfamily 4 group A member 1; NRF1: nuclear respiratory factor 1; OPA1: OPA1 mitochondrial dynamin like GTPase; OPTN: optineurin; PARL: presenilin associated rhomboid like; PARPs: poly(ADP-ribose) polymerases; PC: phosphatidylcholine; PHB2: prohibitin 2; PINK1: PTEN induced kinase 1; PPARG: peroxisome proliferator activated receptor gamma; PPARGC1A: PPARG coactivator 1 alpha; PRKA: protein kinase AMP-activated; PRKDC: protein kinase, DNA-activated, catalytic subunit; PRKN: parkin RBR E3 ubiquitin protein ligase; RHOT: ras homolog family member T; ROS: reactive oxygen species; SIRTs: sirtuins; STK11: serine/threonine kinase 11; TCA: tricarboxylic acid; TP53: tumor protein p53; ULK1: unc-51 like autophagy activating kinase 1; VDAC1: voltage dependent anion channel 1."

Related Drugs and Biologics

1. Transferrin Receptors (Transferrin Receptor)
2. metal transporting protein 1 (ferroportin)
3. Iron
4. Metals
5. Elements
6. Insulin (Novolin)
7. Hepcidins
8. matriptase 2
9. Proteins (Proteins, Gene)
10. Messenger RNA (mRNA)