Can sonographic peritoneal thickness be used to follow pediatric patients on peritoneal dialysis?

Abstract

BACKGROUND:

Peritoneal dialysis (PD) is an effective and successful therapy for end-stage renal disease (ESRD). However, PD does not have a life-long effectiveness, and peritoneal membrane failure is commonly observed in long-term PD patients. We hypothesized that ultrasonography could be used to follow these patients.

METHODS:

We recruited two patient groups (age range 3-18 years), of whom 20 had ESRD with ongoing PD for ≥24 months (study group) and 20 were pre-dialysis non-ESRD patients (control group). None of the patients had peritonitis during the preceding 3 months, and none had a history of abdominal surgery or malignancy. We measured the sonographic thickness of the parietal peritoneum and obtained Doppler indices of the superior mesenteric artery (SMA) by trans-abdominal ultrasonography.

RESULTS:

Peritoneal thickness as determined by sonography was significantly greater in the PD group than in the controls. The correlation between duration of PD and thickness of the peritoneal membrane was linear and statistically significant. We categorized all 20 patients as either rapid transporters or slow transporters for both creatinine and glucose. The peritoneal membranes of patients who were rapid transporters for both creatinine and glucose were significantly thicker than those of the slow transporters. No statistical difference was found between the Doppler indices of the SMA between the groups.

CONCLUSION:

Thickness of the parietal peritoneum as determined by sonography is associated with PD duration and transport characteristics. We conclude that ultrasonography is a non-invasive and practical method which can be useful for following PD patients.

• Authors: Aysun Caltik, Sare Gülfem Akyüz, Mehmet Bülbül, Gökçe Cinar, Ozlem Erdogan, Gülay Demircin
• Journal: Pediatric nephrology (Berlin, Germany) (Pediatr Nephrol) Vol. 28 Issue 5 Pg. 811-7 (May 2013) ISSN: 1432-198X [Electronic] Germany
• PMID: 23299234 (Publication Type: Journal Article)

Chemical References

• Blood Glucose
• Urea

Topics

• Adolescent
• Blood Glucose (metabolism)
• Case-Control Studies
• Child
• Child, Preschool
• Female
• Humans
• Kidney Failure, Chronic (blood, diagnostic imaging, therapy)
• Male
• Mesenteric Artery, Superior (diagnostic imaging)
• Peritoneal Dialysis (adverse effects)
• Peritoneum (diagnostic imaging, metabolism)
• Peritonitis (diagnostic imaging, etiology)
• Predictive Value of Tests
• Risk Factors
• Time Factors
• Treatment Outcome
• Turkey
• Ultrasonography, Doppler
• Urea (metabolism)