Effects of oxandrolone on plasma lipoproteins in patients with type IIa, IIb and IV hyperlipoproteinemia: occurrence of hypo-high density lipoproteinemia.

Abstract

The effects of oxandrolone on plasma lipids and lipoprotein composition in patients with type IIa, IIb and IV hyperlipoproteinemia were investigated. Oxandrolone (4 mg/day, for 28 days) induced a significant reduction in plasma and VLDL triglyceride. Reciprocal elevation of LDL cholesterol was observed in 8 of 10 type IV patients and in 2 of 5 type IIb patients. In patients with type IV hyperlipoproteinemia, significant reduction of plasma apolipoproteinB and VLDL apolipoprotein B and inverse LDL apolipoprotein B increment was observed after treatment with oxandrolone. HDL cholesterol was decreased. Hypo-high density lipoproteinemia defined as HDL cholesterol concentration below 40 mg/100 ml occurred in 7 of 10 type IV, 3 of 6 type IIb and 1 of 4 type IIa patients.

• Authors: T Tamai, T Nakai, S Yamada, T Kobayashi, T Hayashi, Y Kutsumi, R Takeda
• Journal: Artery (Artery) Vol. 5 Issue 2 Pg. 125-43 (Feb 1979) ISSN: 0098-6127 [Print] United States
• PMID: 231951 (Publication Type: Journal Article)

Chemical References

• Lipoproteins
• Lipoproteins, HDL
• Lipoproteins, LDL
• Lipoproteins, VLDL
• Triglycerides
• Oxandrolone
• Cholesterol

Topics

• Adult
• Aged
• Cholesterol (blood)
• Female
• Humans
• Hyperlipoproteinemia Type II (blood, drug therapy)
• Hyperlipoproteinemia Type IV (blood, drug therapy)
• Lipoproteins (blood)
• Lipoproteins, HDL (blood)
• Lipoproteins, LDL (blood)
• Lipoproteins, VLDL (blood)
• Male
• Middle Aged
• Oxandrolone (therapeutic use)
• Triglycerides (blood)