[DRESS syndrome as a result of sulfasalazine use].

Abstract

A 24-year-old female developed DRESS syndrome (Drug Reaction with Eosinophilia and Systemic Symptoms) as a result of sulfasalazine use. The DRESS syndrome is a severe and acute hypersensitivity reaction that can be caused by a variety of drugs. The clinical presentation is diverse; the most common symptoms are fever, exanthema and lymphadenopathy. Haematologic abnormalities such as leukocytosis, accompanied primarily with eosinophilia, and sometimes atypical lymphocytes are also frequently reported. In most cases the DRESS syndrome needs no further treatment after discontinuation of the associated drug. However, 20% of patients are severely affected and the DRESS syndrome is potentially life-threatening. The patient was successfully treated with a glucocorticoid and an antihistamine.

• Authors: Sophie C van der Mark, Dolf Segers, René C Bakker, Peter van Wijngaarden
• Journal: Nederlands tijdschrift voor geneeskunde (Ned Tijdschr Geneeskd) Vol. 154 Issue 18 Pg. A2161 ( 2010) ISSN: 1876-8784 [Electronic] Netherlands
• Vernacular Title: Het DRESS-syndroom bij gebruik van sulfasalazine.
• PMID: 23134745 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Glucocorticoids
• Histamine Antagonists
• Sulfasalazine

Topics

• Anti-Inflammatory Agents, Non-Steroidal (adverse effects, therapeutic use)
• Drug Hypersensitivity (diagnosis, drug therapy, etiology)
• Eosinophilia (chemically induced, diagnosis, drug therapy)
• Exanthema (chemically induced, diagnosis, drug therapy)
• Female
• Glucocorticoids (therapeutic use)
• Histamine Antagonists (therapeutic use)
• Humans
• Sulfasalazine (adverse effects, therapeutic use)
• Syndrome
• Treatment Outcome
• Young Adult