Combination of irinotecan (CPT-11) and nedaplatin (NDP) for recurrent patients with uterine cervical cancer.

Abstract

BACKGROUND:

The clinical activity of combination of irinotecan (CPT-11) and nedaplatin (NDP) for recurrent patients with uterine cervical cancer was evaluated retrospectively.

METHODS:

Intravenous CPT-11 was given at 60 mg/m(2) (days 1, 8, 15), followed by NDP 80 mg/m(2) (day 1), every 4 weeks.

RESULTS:

According to the medical records, 29 cases have received this regimen since 2000. Median age was 57 years (range, 29-80), and performance status (PS) of the patients was 18 cases with PS 0, 10 cases with PS 1, and 1 case with PS 2, respectively. Clinical stage was as follows: 3 cases of stage Ib1, 2 cases of Ib2, 2 cases of IIa, 10 cases of IIb, 8 cases of IIIb, and 4 cases of IVb. There were 27 cases of squamous cell carcinoma and 2 cases of adenocarcinoma. Concerning hematological toxicity of grade 3 or more, neutropenia, leukopenia, and febrile neutropenia were observed in 79.3 %, 96.6 %, and 13.8 % of cases, respectively. For nonhematological toxicity, nausea, anorexia, joint pain, and confusion were observed in only 1 case, respectively, and as a result, in 7 cases chemotherapy was not completed. Among 26 cases with clinically evaluable lesions, there were 7 complete responses, 3 partial responses, 7 stable disease, and 9 progressive disease; the clinical response rate was 38.5 %. Median progression-free survival was 7 months (range, 0-38 months).

CONCLUSION:

The combination of CPT-11 and NDP seems to be active for patients with recurrent uterine cervical cancer.

• Authors: Tatsuru Ohara, Yoichi Kobayashi, Ayako Yoshida, Norihito Yoshioka, Namiko Yahagi, Haruhiro Kondo, Akiko Tozawa, Kazushige Kiguchi, Nao Suzuki
• Journal: International journal of clinical oncology (Int J Clin Oncol) Vol. 18 Issue 6 Pg. 1102-6 (Dec 2013) ISSN: 1437-7772 [Electronic] Japan
• PMID: 23095879 (Publication Type: Journal Article)

Chemical References

• Organoplatinum Compounds
• Irinotecan
• nedaplatin
• Cisplatin
• Camptothecin

Topics

• Adult
• Aged
• Aged, 80 and over
• Antineoplastic Combined Chemotherapy Protocols (administration & dosage, adverse effects)
• Camptothecin (administration & dosage, adverse effects, analogs & derivatives)
• Cisplatin (administration & dosage)
• Disease-Free Survival
• Female
• Humans
• Irinotecan
• Middle Aged
• Neoplasm Recurrence, Local (drug therapy, pathology)
• Neoplasm Staging
• Organoplatinum Compounds (administration & dosage, adverse effects)
• Uterine Cervical Neoplasms (classification, drug therapy, pathology)