Abstract | BACKGROUND: OBJECTIVE: METHODS: 39 patients were divided into four groups of: 1) active (acute phase of treatment); 2) non-healing (received treatment for almost two years without recovery); 3) healing (recovered upon treatment); and 4) healed (previously received treatment and achieved complete remission) patients. Serum levels of pro-inflammatory cytokines (IL-1B, TNF-α, IL-6) and serum antioxidant levels were measured by ELISA and FRAP assays, respectively. RESULTS: While serum antioxidant levels were elevated in the non-healing group, there was no difference among other groups of patients and healthy controls in this regard. Interleukin-1β showed the highest level in the non-healing group followed by the other groups of patients. The mean serum IL-6 level was highest in the non-healing group, but showed no significant change in the other groups. TNF-α and IL-1β levels were non-significantly elevated in the sera of active and non-healing patients. CONCLUSION:
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Authors | Afshineh Latifynia, Ali Khamesipour, Saied Bokaie, Nematollah Khansari |
Journal | Iranian journal of immunology : IJI
(Iran J Immunol)
Vol. 9
Issue 3
Pg. 208-14
(Sep 2012)
ISSN: 1735-367X [Electronic] Iran |
PMID | 23023385
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Cytokines
(blood)
- Disease Progression
- Humans
- Leishmaniasis, Cutaneous
(blood, drug therapy)
- Prognosis
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