[Relationship between mannose-binding protein gene polymorphisms and disease progression and HBV DNA in patients with chronic HBV infection].

Abstract

OBJECTIVE:

To determine the influences of Mannose binding protein (MBP) gene polymorphisms on HBV DNA loads and on the progression of liver disease in patients with chronic HBV infection.

METHOD:

The Codons on 54 MBP gene polymorphisms and HBV DNA loads in a cohort of 395 patients with chronic HBV infection, including 244 with chronic hepatitis B (CHB), 151 with liver cirrhosis (LC) and 88 normal controls were examined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and fluorescent quantitative PCR (FQ-PCR).

RESULT:

The MBP genotype frequencies of GGC/GAC and alleles genetic frequencies of GAC in CHB group showed no significant differences comparing to the normal control group (P > 0.05). The MBP genotype frequencies of GGC/GAC and alleles genetic frequencies of GAC on CHB group (severe), compensation phase of LC group and decompensation phase of LC group were higher than those in the normal control group (P < 0.05), the genetic polymorphism of decompensation of LC was 36.5%, highest of all. The MBP genotype frequencies of GGC/GAC and alleles genetic frequencies of GAC of patients with chronic HBV infection were not changed with the differences of HBV-DNA loads.

CONCLUSION:

The codes on 54 MBP gene polymorphisms is not closely related to HBV DNA loads, but was associated with the progression of hepatitis B infection.

• Authors: Rui-Dan Zheng, Jian-Neng Chen, Jian-Ping Gao, Qun-Ying Zhuang, Qing-Chuan Zhu, Yan-Hui Lu, Zhen-Qun Lin, Wu-Hua Hong, Qing-Duan Li, Zhe Chen
• Journal: Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology (Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi) Vol. 26 Issue 2 Pg. 90-2 (Apr 2012) ISSN: 1003-9279 [Print] China
• PMID: 23002541 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• DNA, Viral
• Mannose-Binding Lectin

Topics

• Adolescent
• Adult
• Aged
• Cohort Studies
• DNA, Viral (analysis)
• Disease Progression
• Female
• Gene Frequency
• Genotype
• Hepatitis B, Chronic (genetics)
• Humans
• Male
• Mannose-Binding Lectin (genetics)
• Middle Aged
• Polymorphism, Genetic