Increased serum heat shock protein 27 antibody titers and prooxidant-antioxidant balance in patients with beta-thalassemia major.

Abstract

OBJECTIVE:

Determination of the serum heat shock protein 27 (Hsp27) antibody titers and prooxidant-antioxidant balance (PAB) in patients with thalassemia as markers of cell and oxidative stress, respectively.

METHODS:

Serum PAB and anti-Hsp27 antibody titers were measured in 140 patients with thalassemia major and 140 sex- and age-matched healthy volunteers.

RESULTS:

A significantly higher serum PAB value was observed in patients in comparison to controls. In the patient group, anti-Hsp27 antibody titers were significantly higher than for the control group (p < 0.001). We found a weak negative correlation between anti-Hsp27 antibody concentrations and the PAB (p = 0.03), but these values were not correlated with serum superoxide dismutase activity in the thalassemic patients.

CONCLUSIONS:

Increased levels of serum PAB and Hsp27 antibodies may be involved in the pathological consequences of β-thalassemia major and may contribute to the development of endothelial injury.

• Authors: Elham Ghahremanlu, Abdollah Banihashem, Hamidreza Saber, Shima Tavallaie, Naghmeh Mirhosseini, Majid Ghayour-Mobarhan, Gordon A A Ferns
• Journal: Acta haematologica (Acta Haematol) Vol. 129 Issue 1 Pg. 1-9 ( 2013) ISSN: 1421-9662 [Electronic] Switzerland
• PMID: 22964881 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 S. Karger AG, Basel.

Chemical References

• Antibodies
• Antioxidants
• HSP27 Heat-Shock Proteins
• Oxidants
• Superoxide Dismutase

Topics

• Adolescent
• Antibodies (blood)
• Antioxidants (metabolism)
• Child
• Demography
• Female
• HSP27 Heat-Shock Proteins (immunology)
• Humans
• Male
• Oxidants (blood)
• Superoxide Dismutase (metabolism)
• Young Adult
• beta-Thalassemia (metabolism, pathology)