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HSP27 Heat-Shock Proteins

Subscribe to New Research on HSP27 Heat-Shock Proteins

A subfamily of small heat-shock proteins that function as molecular chaperones that aid in refolding of non-native proteins. They play a protective role that increases cellular survival during times of stress.

Also Known As:

HSP27 Protein; HSP27 Proteins; Heat Shock Protein beta-1; Heat-Shock Protein 27; Heat-Shock Proteins 27; HSP27 Heat Shock Proteins; Heat Shock Protein 27; Heat Shock Protein beta 1; Heat Shock Proteins 27; Heat-Shock Proteins, HSP27; Protein 27, Heat-Shock

Networked: 464 relevant articles (8 outcomes, 55 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489
  - Molecular Chaperones: 904
    - Heat-Shock Proteins: 6371
      - Small Heat-Shock Proteins: 117
        HSP27 Heat-Shock Proteins: 464
        human HSPB1 protein
        human HSPB2 protein
        human HSPB7 protein
        mouse Hspb2 protein
        rat Hspb1 protein
        rat Hspb2 protein
        zebrafish Hsp27 protein

Experts

1.	Ghayour-Mobarhan, Majid: 11 articles (03/2014 - 06/2008)
2.	Rocchi, Palma: 10 articles (04/2014 - 09/2004)
3.	Tavallaie, Shima: 10 articles (03/2014 - 06/2008)
4.	Kuramitsu, Yasuhiro: 9 articles (11/2015 - 12/2007)
5.	Nakamura, Kazuyuki: 8 articles (07/2015 - 12/2007)
6.	O'Brien, Edward R: 8 articles (02/2014 - 03/2005)
7.	Gleave, Martin: 8 articles (10/2013 - 09/2004)
8.	Sakaida, Isao: 7 articles (01/2014 - 12/2007)
9.	Chen, Yong-Xiang: 7 articles (10/2013 - 03/2005)
10.	Rayner, Katey: 6 articles (10/2013 - 03/2005)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 01/01/2007 - "This study utilized two breast cancer cell lines differing only in their expression of heat shock protein 27 (hsp27). " 12/05/2014 - "Finally, we applied this approach to determine the phosphorylation stoichiometry of heat shock protein 27 (HSP27) at Ser78 and Ser82 in breast cancer cells and tissue samples." 05/29/2012 - "Suppression of heat shock protein 27 induces long-term dormancy in human breast cancer." 01/15/2011 - "Heat shock protein 27 differentiates tolerogenic macrophages that may support human breast cancer progression." 07/01/2007 - "Heat shock protein 27 (HSP27), which is highly expressed in human lung and breast cancer tissues, induced resistance to cell death against various stimuli. "
2.	Neoplasms (Cancer) 05/01/2013 - "In many tumors, the heat shock protein 27 (Hsp27) is expressed at high levels to provide protection against anticancer drugs. " 07/01/2014 - "Previous studies have indicated that heat shock protein 27 (HSP27) had high correlation with the development and progression in several tumors. " 11/05/2015 - "Here, we demonstrate that heat shock protein beta-1 (HSPB1) is a negative regulator of ferroptotic cancer cell death. " 01/01/2014 - "Heat shock protein 27 phosphorylation state is associated with cancer progression." 01/01/2014 - "The nuclear localization of NLK was mediated through direct interaction with Heat shock protein 27 (HSP27) which further protected cancer cells from apoptosis. "
3.	Shock 07/01/1989 - "The presence of additional HSP27 protein provides immediate protection against heat shock administered 48 h after transfection and confers a permanent thermoresistant phenotype to stable transfectant Chinese hamster and mouse cell lines. " 12/30/1993 - "While preliminary expression studies indicate the promoter directs heat shock induced expression of heat shock protein 27, the functional significance of the intronic heat shock element to the expression of this gene remains to be determined." 09/01/2015 - "PTS increased the expression of heat shock factor (HSF) 2, but not HSF1, resulting in activation of heat shock protein 27. " 04/01/2008 - "On the basis of in vitro acute toxicity assay using heat shock factor-1 (HSF-1) wild-type (HSF-1(+/+)) and HSF-1-knockout (HSF-1(-/-)) mouse embryonic fibroblasts and neonatal rat cardiomyocyte-derived H9c2 cells, we demonstrate a novel mechanism whereby heat shock protein 27 (HSP27) regulates transcriptional activity of p53 in Dox-treated cells. " 11/01/2007 - "In this work, using heat shock factor-1 wild-type (HSF-1(+/+)) and HSF-1 knockout (HSF-1(-/-)) mouse fibroblasts and embryonic rat heart-derived cardiac H9c2 cells, we show that the magnitude of protection from Dox-induced toxicity directly correlates with the level of the heat shock protein 27 (HSP27). "
4.	Colorectal Neoplasms (Colorectal Cancer) 11/01/2010 - "In a preliminary proteomic study, variation in the levels of heat shock protein 27 (HSP27) in colorectal cancer samples was observed. " 03/01/2010 - "To investigate the expression of 14-3-3 sigma and heat shock protein 27 (HSP27) in colorectal carcinoma(CRC) tissue and its clinical significance. " 03/01/2010 - "[Expression and clinical significance of 14-3-3 sigma and heat shock protein 27 in colorectal cancer]." 01/01/2015 - "Stromal expression of heat-shock protein 27 is associated with worse clinical outcome in patients with colorectal cancer lung metastases." 01/01/2008 - "To investigate the relationship between heat shock protein 27 (HSP27) expression and lymphatic metastasis of colorectal carcinoma (CRC). "
5.	Myocardial Ischemia (Ischemic Heart Diseases) 06/01/2010 - "Heat shock protein 27 (Hsp27) has been considered to be a potentially therapeutic protein for the treatment of ischemic heart disease due to its anti-apoptotic and protective effects on cardiomyocytes under stressful conditions. " 11/16/2007 - "These results suggest that the PTD-mediated delivery of HSP27 protein may represent a potential therapeutic strategy as protein drug for ischemic heart diseases." 12/01/2007 - "Research in animal and cell models demonstrates that acute myocardial ischemia/reperfusion injury causes phosphorylation of heat shock protein 27 and alphaB-crystallin. " 11/01/2007 - "[Protective effect of heat-shock protein 27 on myocardium with isoflurane preconditioning in myocardial ischemia/reperfusion injury of myocardium in rabbit]."

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Glutathione Transferase (Glutathione S-Transferase)
3.	Paclitaxel (Taxol)
4.	Doxorubicin (Adriamycin)
5.	Antibodies
6.	HMGB1 Protein (HMG1)
7.	Annexin A4
8.	gemcitabine
9.	Estrogens (Estrogen)
10.	HSP27 Heat-Shock Proteins

Related Therapies and Procedures

1.	Castration
2.	Prostatectomy (Retropubic Prostatectomy)
3.	Ischemic Postconditioning
4.	Drug Therapy (Chemotherapy)
5.	Therapeutics