Abstract | BACKGROUND: METHODS AND RESULTS: A total of 652 patients with stable CAD were studied. All patients underwent percutaneous coronary intervention and successful revascularization. Major adverse cardiovascular events ( MACE) were defined as a composite of events of CHF, recurrence of angina pectoris, acute myocardial infarction, stroke, critical arrhythmia, intervention to peripheral arteries and cardiac death. The mean follow-up period was 973±639 days. MACE occurred in 108 patients (16.6%). Plasma S100A12 level had a significant positive correlation with high-sensitivity C-reactive protein ( hs-CRP) level. On Kaplan-Meier curve analysis the incidence of MACE was significantly different among S100A12 quartiles (P=0.026). The highest S100A12 quartile (Q4) had a significantly higher MACE rate than the lowest quartile (Q1) (P=0.002). In contrast, hs-CRP was not significant for predicting MACE in the present subjects (P=0.074). A Cox proportional hazard model showed that S100A12 was an independent factor for predicting MACE in multivariate models. CONCLUSIONS:
S100A12 could be a novel biomarker for predicting cardiovascular events for predicting MACE in patients with stable CAD.
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Authors | Toshinobu Saito, Yukihiro Hojo, Yukako Ogoyama, Masahiro Hirose, Tomokazu Ikemoto, Takaaki Katsuki, Kazuyuki Shimada, Kazuomi Kario |
Journal | Circulation journal : official journal of the Japanese Circulation Society
(Circ J)
Vol. 76
Issue 11
Pg. 2647-52
( 2012)
ISSN: 1347-4820 [Electronic] Japan |
PMID | 22786469
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Biomarkers
- S100 Proteins
- S100A12 Protein
- S100A12 protein, human
- C-Reactive Protein
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Topics |
- Aged
- Biomarkers
(blood)
- C-Reactive Protein
(metabolism)
- Cardiovascular Diseases
(blood, etiology, mortality)
- Chronic Disease
- Coronary Artery Disease
(blood, complications, mortality)
- Death
- Female
- Humans
- Male
- Middle Aged
- Predictive Value of Tests
- S100 Proteins
(blood)
- S100A12 Protein
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