Abstract | PURPOSE OF REVIEW: RECENT FINDINGS:
Hypersensitivity reactions to PPI vary from mild symptoms to life-threatening disorders. Cases of urticaria, angioedema, anaphylaxis, cytopenia, vasculitis, acute allergic interstitial nephritis, occupational contact dermatitis, photoallergic dermatitis, maculopapular eruption, erythroderma, Drug rash with eosinophilia and systemic symptoms ( DRESS) syndrome, Stevens-Johnson syndrome/toxic epidermal necrolysis, and other autoimmune reactions (including cutaneous lupus erythematosus) have been described. SUMMARY: A high level of clinical suspicion is critical in the diagnosis of PPI-induced hypersensitivity reactions. Physicians should be aware of the possible hypersensitivity reactions due to PPI and routine/empirical prescription for PPI should only be used when clinically indicated.
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Authors | Yoon-Seok Chang |
Journal | Current opinion in allergy and clinical immunology
(Curr Opin Allergy Clin Immunol)
Vol. 12
Issue 4
Pg. 348-53
(Aug 2012)
ISSN: 1473-6322 [Electronic] United States |
PMID | 22744268
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
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Topics |
- Acute Disease
- Anaphylaxis
(chemically induced, diagnosis)
- Angioedema
(chemically induced, diagnosis)
- Dermatitis, Exfoliative
(chemically induced, diagnosis)
- Dermatitis, Photoallergic
(diagnosis)
- Drug Hypersensitivity
(diagnosis)
- Eosinophilia
(chemically induced, diagnosis)
- Female
- Humans
- Lupus Erythematosus, Cutaneous
(chemically induced, diagnosis)
- Male
- Nephritis, Interstitial
(chemically induced, diagnosis)
- Proton Pump Inhibitors
(adverse effects, pharmacology)
- Stevens-Johnson Syndrome
(chemically induced, diagnosis)
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