Abstract | INTRODUCTION: METHODS: RESULTS: CONCLUSIONS: The increased sensitivity of PC-9/Met cells to SN-38 compared with that of PC-9 cells was partially because of topo I activities resulting from increased topo I mRNA and protein expression caused by MET signaling.
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Authors | Asao Sakai, Kazuo Kasahara, Tohru Ohmori, Hideharu Kimura, Takashi Sone, Masaki Fujimura, Shinji Nakao |
Journal | Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
(J Thorac Oncol)
Vol. 7
Issue 9
Pg. 1337-44
(Sep 2012)
ISSN: 1556-1380 [Electronic] United States |
PMID | 22722827
(Publication Type: Journal Article)
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Chemical References |
- Antineoplastic Agents
- Quinazolines
- RNA, Messenger
- RNA, Small Interfering
- Topoisomerase I Inhibitors
- Irinotecan
- MET protein, human
- Proto-Oncogene Proteins c-met
- DNA Topoisomerases, Type I
- TOP1 protein, human
- Gefitinib
- Camptothecin
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Topics |
- Antineoplastic Agents
(pharmacology)
- Blotting, Western
- Camptothecin
(analogs & derivatives, pharmacology)
- Carcinoma, Non-Small-Cell Lung
(drug therapy, metabolism, pathology)
- Cell Proliferation
- DNA Topoisomerases, Type I
(chemistry, metabolism)
- Drug Resistance, Neoplasm
(drug effects)
- Gefitinib
- Humans
- In Situ Hybridization, Fluorescence
- Irinotecan
- Lung Neoplasms
(drug therapy, metabolism, pathology)
- Proto-Oncogene Proteins c-met
(antagonists & inhibitors, genetics, metabolism)
- Quinazolines
(pharmacology)
- RNA, Messenger
(genetics)
- RNA, Small Interfering
(genetics)
- Real-Time Polymerase Chain Reaction
- Reverse Transcriptase Polymerase Chain Reaction
- Signal Transduction
- Topoisomerase I Inhibitors
(pharmacology)
- Tumor Cells, Cultured
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