Abstract | INTRODUCTION: METHODS:
Titanium dental implants were placed in the proximal tibia metaphysis in 38 animals. Twenty-eight rabbits had undergone bilateral ovariectomy and further methylprednisolone administration for 4 weeks to induce osteoporosis. Ten healthy rabbits were used as controls. At week 8, osteoporotic rabbits started saline vehicle or intermittent PTH administration for 12 weeks. Bone mineral density (BMD) was assessed in peri-implant area, lumbar spine, and global and subchondral knee bone at baseline, and weeks 6 and 20. Animal sacrifice was carried out at week 21. Afterward, tibiae were removed for μCT morphometry and undecalcified sections were evaluated by light and scanning electron microscopy. RESULTS: PTH increased bone-to-implant contact compared with control rabbits or vehicle administration in osteoporotic rabbits (P < 0.005). PTH-induced new bone formation around external and internal surfaces of titanium implants led to a significant increase of BMD at peri-implant area in osteoporotic rabbits at week 20, when compared with vehicle (P < 0.005). Likewise, PTH increased BMD in other analysed regions. CONCLUSIONS:
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Authors | M Isabel Almagro, Jorge A Roman-Blas, Miriam Bellido, Santos Castañeda, Raul Cortez, Gabriel Herrero-Beaumont |
Journal | Clinical oral implants research
(Clin Oral Implants Res)
Vol. 24
Issue 9
Pg. 1027-34
(Sep 2013)
ISSN: 1600-0501 [Electronic] Denmark |
PMID | 22626278
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2012 John Wiley & Sons A/S. |
Chemical References |
- Glucocorticoids
- Parathyroid Hormone
- Titanium
- Methylprednisolone
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Topics |
- Animals
- Bone Density
(drug effects)
- Disease Models, Animal
- Female
- Glucocorticoids
- Implants, Experimental
- Methylprednisolone
- Osseointegration
(drug effects)
- Osteoporosis
(drug therapy, etiology)
- Ovariectomy
- Parathyroid Hormone
(pharmacology)
- Rabbits
- Surface Properties
- Tibia
(diagnostic imaging, surgery)
- Titanium
(chemistry)
- X-Ray Microtomography
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