Abstract | BACKGROUND: PATIENTS AND METHODS: RESULTS: Higher TYMS expression was associated with greater age, DPYD expression with greater age, poorer differentiation and low invasion, and TYMP expression with poorer differentiation and lack of peritoneal metastasis. DPYD expression positively correlated with TYMP expression. In patients with stage IV disease, high DPYD or TYMP expression was associated with poor outcomes. CONCLUSION:
mRNA expression of TYMS, DPYD, and TYMP is associated with distinct characteristics and may be useful for predicting survival in patients with stage IV colorectal cancer.
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Authors | Tetsuhiro Goto, Kazuki Shinmura, Kazuaki Yokomizo, Kazuma Sakuraba, Youhei Kitamura, Atsushi Shirahata, Mitsuo Saito, Gaku Kigawa, Hiroshi Nemoto, Yutaka Sanada, Kenji Hibi |
Journal | Anticancer research
(Anticancer Res)
Vol. 32
Issue 5
Pg. 1757-62
(May 2012)
ISSN: 1791-7530 [Electronic] Greece |
PMID | 22593457
(Publication Type: Journal Article)
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Chemical References |
- RNA, Messenger
- Dihydrouracil Dehydrogenase (NADP)
- Thymidylate Synthase
- TYMP protein, human
- Thymidine Phosphorylase
- Fluorouracil
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Colorectal Neoplasms
(drug therapy, enzymology, mortality, pathology)
- Dihydrouracil Dehydrogenase (NADP)
(genetics)
- Female
- Fluorouracil
(therapeutic use)
- Gene Expression Regulation, Neoplastic
- Humans
- Male
- Middle Aged
- Neoplasm Staging
- RNA, Messenger
(analysis)
- Thymidine Phosphorylase
(genetics)
- Thymidylate Synthase
(genetics)
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