Cytokines in pericardial effusion of patients with inflammatory pericardial disease.

Abstract

BACKGROUND:

The role of inflammatory and angiogenic cytokines in patients with inflammatory pericardial effusion still remains uncertain.

METHODS:

We assessed pericardial and serum levels of VEGF, bFGF, IL-1β and TNF-α by ELISA in patients with inflammatory pericardial effusion (PE) of autoreactive (n = 22) and viral (n = 11) origin, and for control in pericardial fluid (PF) and serum (n = 26) of patients with coronary artery disease (CAD) undergoing coronary artery bypass graft surgery.

RESULTS:

VEGF levels were significantly higher in patients with autoreactive and viral PE than in patients with CAD in both PE (P = 0.006 for autoreactive and P < 0.001 for viral PE) and serum (P < 0.001 for autoreactive and P < 0.001 for viral PE). Pericardial bFGF levels were higher compared to serum levels in patients with inflammatory PE and patients with CAD (P ≤ 0.001 for CAD; P ≤ 0.001 for autoreactive PE; P = 0, 005 for viral PE). Pericardial VEGF levels correlated positively with markers of pericardial inflammation, whereas pericardial bFGF levels showed a negative correlation. IL-1β and TNF-α were detectable only in few PE and serum samples.

CONCLUSIONS:

VEGF and bFGF levels in pericardial effusion are elevated in patients with inflammatory PE. It is thus possible that VEGF and bFGF participate in the pathogenesis of inflammatory pericardial disease.

• Authors: Konstantinos Karatolios, Rainer Moosdorf, Bernhard Maisch, Sabine Pankuweit
• Journal: Mediators of inflammation (Mediators Inflamm) Vol. 2012 Pg. 382082 ( 2012) ISSN: 1466-1861 [Electronic] United States
• PMID: 22577248 (Publication Type: Journal Article)

Chemical References

• Cytokines
• Interleukin-1beta
• Tumor Necrosis Factor-alpha
• Vascular Endothelial Growth Factor A
• Fibroblast Growth Factor 2

Topics

• Aged
• Coronary Artery Bypass (methods)
• Cytokines (blood)
• Enzyme-Linked Immunosorbent Assay (methods)
• Female
• Fibroblast Growth Factor 2 (metabolism)
• Humans
• Immunoassay (methods)
• Inflammation
• Interleukin-1beta (metabolism)
• Male
• Middle Aged
• Pericardial Effusion (immunology)
• Pericardium (pathology)
• Tumor Necrosis Factor-alpha (metabolism)
• Vascular Endothelial Growth Factor A (metabolism)