Abstract |
Our previous study revealed that resveratrol blocks prion protein peptide PrP(106-126)-induced neurotoxicity. However, the mechanism of resveratrol-mediated neuroprotection in prion diseases is not clear. Resveratrol initiates neuroprotective effects via the activation of autophagy, which protects organelles, cells, and organisms against misfolded protein-disorders, including Alzheimer's disease and Parkinson's disease via regulation of mitochondrial homeostasis. Thus, we focused on elucidating the mechanisms responsible for resveratrol-mediated neuroprotection related to mitochondrial homeostasis as a result of autophagy activation. Resveratrol prevented PrP(106-126)-induced neuronal cell death by activating autophagy. Moreover, resveratrol-induced autophagy prevented the PrP(106-126)-induced reduction in mitochondrial potential and translocation of Bax to the mitochondria and cytochrome c release. Our results indicate that treatment with resveratrol appears to protect against neurotoxicity caused by prion protein peptides and the neuroprotection is induced by resveratrol-mediated autophagy signals.
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Authors | Jae-Kyo Jeong, Myung-Hee Moon, Bum-Chul Bae, You-Jin Lee, Jae-Won Seol, Hyung-Sub Kang, Jin-Shang Kim, Seog-Jin Kang, Sang-Youel Park |
Journal | Neuroscience research
(Neurosci Res)
Vol. 73
Issue 2
Pg. 99-105
(Jun 2012)
ISSN: 1872-8111 [Electronic] Ireland |
PMID | 22465415
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2012 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved. |
Chemical References |
- Neuroprotective Agents
- Peptide Fragments
- Prions
- Stilbenes
- prion protein (106-126)
- Resveratrol
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Topics |
- Autophagy
(drug effects, physiology)
- Cell Line, Tumor
- Humans
- Mitochondria
(drug effects, physiology)
- Neuroprotective Agents
(pharmacology)
- Peptide Fragments
(antagonists & inhibitors, toxicity)
- Prions
(antagonists & inhibitors, toxicity)
- Resveratrol
- Stilbenes
(pharmacology)
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