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Autophagy induced by resveratrol prevents human prion protein-mediated neurotoxicity.

Abstract
Our previous study revealed that resveratrol blocks prion protein peptide PrP(106-126)-induced neurotoxicity. However, the mechanism of resveratrol-mediated neuroprotection in prion diseases is not clear. Resveratrol initiates neuroprotective effects via the activation of autophagy, which protects organelles, cells, and organisms against misfolded protein-disorders, including Alzheimer's disease and Parkinson's disease via regulation of mitochondrial homeostasis. Thus, we focused on elucidating the mechanisms responsible for resveratrol-mediated neuroprotection related to mitochondrial homeostasis as a result of autophagy activation. Resveratrol prevented PrP(106-126)-induced neuronal cell death by activating autophagy. Moreover, resveratrol-induced autophagy prevented the PrP(106-126)-induced reduction in mitochondrial potential and translocation of Bax to the mitochondria and cytochrome c release. Our results indicate that treatment with resveratrol appears to protect against neurotoxicity caused by prion protein peptides and the neuroprotection is induced by resveratrol-mediated autophagy signals.
AuthorsJae-Kyo Jeong, Myung-Hee Moon, Bum-Chul Bae, You-Jin Lee, Jae-Won Seol, Hyung-Sub Kang, Jin-Shang Kim, Seog-Jin Kang, Sang-Youel Park
JournalNeuroscience research (Neurosci Res) Vol. 73 Issue 2 Pg. 99-105 (Jun 2012) ISSN: 1872-8111 [Electronic] Ireland
PMID22465415 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2012 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
Chemical References
  • Neuroprotective Agents
  • Peptide Fragments
  • Prions
  • Stilbenes
  • prion protein (106-126)
  • Resveratrol
Topics
  • Autophagy (drug effects, physiology)
  • Cell Line, Tumor
  • Humans
  • Mitochondria (drug effects, physiology)
  • Neuroprotective Agents (pharmacology)
  • Peptide Fragments (antagonists & inhibitors, toxicity)
  • Prions (antagonists & inhibitors, toxicity)
  • Resveratrol
  • Stilbenes (pharmacology)

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