Inhibitory effects of water-soluble low-molecular-weight β-(1,3-1,6) D-glucan isolated from Aureobasidium pullulans 1A1 strain black yeast on mast cell degranulation and passive cutaneous anaphylaxis.

Abstract	We investigated the effects of water-soluble low-molecular-weight β-(1,3-1,6) D-glucan isolated from Aureobasidium pullulans 1A1 strain black yeast (LMW-β-glucan) on mast cell-mediated anaphylactic reactions. Although it is known that LMW-β-glucan has anti-tumor, anti-metastatic and anti-stress effects, the roles of LMW-β-glucan in immediate-type allergic reactions have not been fully investigated. We examined whether LMW-β-glucan could inhibit mast cell degranulation and passive cutaneous anaphylaxis (PCA). LMW-β-glucan dose-dependently inhibited the degranulation of both rat basophilic leukemia (RBL-2H3) and cultured mast cells (CMCs) activated by calcium ionophore A23187 or IgE. However, LMW-β-glucan had no cytotoxicity towards RBL-2H3 cells and CMCs. Furthermore, orally administered LMW-β-glucan inhibited the IgE-induced PCA reaction in mice. These results show LMW-β-glucan to be a possible compound for the effective therapeutic treatment of allergic diseases.
Authors	Harumi Sato, Yuko Kobayashi, Atsushi Hattori, Toshio Suzuki, Munekazu Shigekawa, Tomoko Jippo
Journal	Bioscience, biotechnology, and biochemistry (Biosci Biotechnol Biochem) Vol. 76 Issue 1 Pg. 84-8 ( 2012) ISSN: 1347-6947 [Electronic] England
PMID	22232243 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Anti-Allergic Agents Glucans epiglucan Water Immunoglobulin E
Topics	Administration, Oral Animals Anti-Allergic Agents (administration & dosage, chemistry, isolation & purification, pharmacology) Ascomycota (chemistry) Bone Marrow Cells (cytology) Capillary Permeability (drug effects) Cell Degranulation (drug effects) Cell Line, Tumor Cell Survival (drug effects) Female Glucans (administration & dosage, chemistry, isolation & purification, pharmacology) Immunoglobulin E (immunology) Mast Cells (cytology, drug effects) Mice Mice, Inbred ICR Molecular Weight Passive Cutaneous Anaphylaxis (drug effects, immunology) Rats Solubility Water (chemistry)

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