Resveratrol protects left ventricle by increasing adenylate kinase and isocitrate dehydrogenase activities in rats with myocardial infarction.

Abstract	Our prior study had shown that resveratrol was a potent cardioprotective agent in rats with myocardial infarction (MI). In this study, we further evaluated the mechanism of cardioprotection of resveratrol by proteomic analysis. After permanent ligation of the left anterior descending artery under isoflurane anesthesia, surviving rats were randomly allocated to three groups and treated with resveratrol at 1 mg/kg/day (MI/R group), or vehicles (sham group and MI group) once daily for four weeks. In proteomic analysis, the MI group showed decreased expression of adenylate kinase 1 (AK1) and mitochondrial NADP⁺-dependent isocitrate dehydrogenase (IDPm) after MI compared with the sham group. These variations were reversed by resveratrol in the MI/R group. Validation with Western blot and immunohistochemical analyses showed similar trends in protein expression profiling. Our studies suggest that the beneficial effects of resveratrol on ventricular modeling may be due to increased expression of AK1 and IDPm, which have been known to increase myocardial energetic efficiency and reduce reactive oxygen species-mediated damage, respectively.
Authors	Jeng-Feng Lin, Semon Wu, Shiang-Suo Huang, Bo-Yi Lu, Su-Man Lin, Shen-Kou Tsai
Journal	The Chinese journal of physiology (Chin J Physiol) Vol. 54 Issue 6 Pg. 406-12 (Dec 31 2011) ISSN: 0304-4920 [Print] India
PMID	22229508 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Antioxidants Cardiotonic Agents Stilbenes Isocitrate Dehydrogenase Adenylate Kinase adenylate kinase 1 Resveratrol
Topics	Adenylate Kinase (analysis, metabolism) Animals Antioxidants (pharmacology) Blotting, Western Cardiotonic Agents (pharmacology) Disease Models, Animal Electrophoresis, Gel, Two-Dimensional Energy Metabolism (drug effects) Enzyme Activation (drug effects) Immunohistochemistry Isocitrate Dehydrogenase (analysis, metabolism) Male Myocardial Infarction (drug therapy, enzymology, pathology) Myocardium (enzymology, pathology) Rats Rats, Sprague-Dawley Resveratrol Stilbenes (pharmacology) Ventricular Remodeling (drug effects)

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